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LDN-57444

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For Research Use Only | Not For Clinical Use
CATAP668467912-A
CAS668467-91-2
MDL NumberMFCD09037562
Molecular Weight397.64
InChI KeyOPQRFPHLZZPCCH-PGMHBOJBSA-N
Description≥98% (HPLC)
SolubilityDMSO: 16 mg/mL
Assay≥98% (HPLC)
Formsolid; protect from light
Size5MG, 25MG
Storage Conditions2-8°C
1

Inhibition of UCHL1 by LDN-57444 Attenuates Ang II-Induced Atrial Fibrillation in Mice

Hai-Lian Bi, Yun-Long Zhang, Jie Yang, Qing Shu, Xiao-Lei Yang, Xiao Yan, Chen Chen, Zhi Li, Hui-Hua Li

Hypertens Res. 2020 Mar;43(3):168-177.

PMID: 31700166

1

Inhibition of UCH-L1 Deubiquitinating Activity With Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells

Eiji Kobayashi, Duhyeong Hwang, Anjali Bheda-Malge, Christopher B Whitehurst, Alexander V Kabanov, Satoru Kondo, Mitsuharu Aga, Tomokazu Yoshizaki, Joseph S Pagano, Marina Sokolsky, Julia Shakelford

Int J Mol Sci. 2019 Jul 31;20(15):3733.

PMID: 31370144

1

Ubiquitin C-terminal Hydrolase 1: A Novel Functional Marker for Liver Myofibroblasts and a Therapeutic Target in Chronic Liver Disease

Caroline L Wilson, Lindsay B Murphy, Jack Leslie, Stuart Kendrick, Jeremy French, Christopher R Fox, Neil S Sheerin, Andrew Fisher, John H Robinson, Dina G Tiniakos, Douglas A Gray, Fiona Oakley, Derek A Mann

J Hepatol. 2015 Dec;63(6):1421-8.

PMID: 26264933

1

Ubiquitin C-Terminal Hydrolase L1 Regulates Autophagy by Inhibiting Autophagosome Formation Through Its Deubiquitinating Enzyme Activity

Cong Yan, Huanhuan Huo, Cuiwei Yang, Tao Zhang, Yuanyuan Chu, Yanfen Liu

Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733.

PMID: 29462615

1

UCH-L1 Inhibition Aggravates Mossy Fiber Sprouting in the Pentylenetetrazole Kindling Model

Yuetao Wen, Qingyuan Wu, Quanhong Shi, Yanfeng Xie, Wei Dan, YangMei Chen, Limin Ma

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2312-2318.

PMID: 29964011

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