Leflunomide Related Compound A

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For Research Use Only | Not For Clinical Use

CAT	AP455141-A
CAS	455-14-1
Structure
MDL Number	MFCD00064396
Molecular Weight	161.12
EC Number	207-236-5
InChI Key	ODGIMMLDVSWADK-UHFFFAOYSA-N
REAXYS Number	1564853

Description	Pharmaceutical Secondary Standard; Certified Reference Material
Density	1.283 g/mL at 25 °C (lit.); traceable to USP 1357045
BP	83 °C/12 mmHg (lit.)
Grade	certified reference material; pharmaceutical secondary standard
Linear Formula	CF3C6H4NH2
Refractive Index	n20/D 1.483 (lit.)
Size	200MG

Comparison of Two Molecular Scaffolds, 5-methylisoxazole-3-carboxamide and 5-methylisoxazole-4-carboxamide

Yaoming Song, Yiguan Zhang, An-Rong Lee, Wen-Hsin Huang, Ben Chen, Bruce Palfey, Jiajiu Shaw

Curr Pharm Des. 2014;20(1):146-52.

PMID: 23944378

Inhibition of Dihydroorotate Dehydrogenase by the Immunosuppressive Agent Leflunomide

S Greene, K Watanabe, J Braatz-Trulson, L Lou

Biochem Pharmacol. 1995 Sep 7;50(6):861-7.

PMID: 7575649

Synthesis, Structure-Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] Propenamide and Related Compounds

E A Kuo, P T Hambleton, D P Kay, P L Evans, S S Matharu, E Little, N McDowall, C B Jones, C J Hedgecock, C M Yea, A W Chan, P W Hairsine, I R Ager, W R Tully, R A Williamson, R Westwood

J Med Chem. 1996 Nov 8;39(23):4608-21.

PMID: 8917650

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