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LFM-A13

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For Research Use Only | Not For Clinical Use
CATAP244240242
CAS244240-24-2
MDL NumberMFCD09878279
Molecular Weight360.00
InChI KeyUVSVTDVJQAJIFG-VURMDHGXSA-N
Description≥98% (HPLC), powder
SolubilityDMSO: ≥19 mg/mL
Assay≥98% (HPLC)
Colorwhite to tan
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Anti-breast Cancer Activity of LFM-A13, a Potent Inhibitor of Polo-like Kinase (PLK)

Fatih M Uckun, Ilker Dibirdik, Sanjive Qazi, Alexei Vassilev, Hong Ma, Chen Mao, Alexey Benyumov, Katayoon H Emami

Bioorg Med Chem. 2007 Jan 15;15(2):800-14.

PMID: 17098432

1

Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer

Anna Tankiewicz-Kwedlo, Justyna Magdalena Hermanowicz, Krystyna Pawlak, Robert Czarnomysy, Krzysztof Bielawski, Izabela Prokop, Dariusz Pawlak

Int J Mol Sci. 2018 Apr 23;19(4):1262.

PMID: 29690619

1

Inhibitor of Tec Kinase, LFM-A13, Decreases Pro-Inflammatory Mediators Production in LPS-stimulated RAW264.7 Macrophages via NF-κB Pathway

Fei Wang, Wei Zhang, Chao Wang, Xu Fang, Hao Cheng, Sheng Liu, Xu-Lin Chen

Oncotarget. 2017 May 23;8(21):34099-34110.

PMID: 28415764

1

LFM-A13, a Potent Inhibitor of Polo-Like Kinase, Inhibits Breast Carcinogenesis by Suppressing Proliferation Activity and Inducing Apoptosis in Breast Tumors of Mice

Kazim Sahin, Mehmet Tuzcu, Mehmet Yabas, Cemal Orhan, Nurhan Sahin, Ibrahim H Ozercan

Invest New Drugs. 2018 Jun;36(3):388-395.

PMID: 29139009

1

Simultaneous Use of Erythropoietin and LFM-A13 as a New Therapeutic Approach for Colorectal Cancer

Anna Tankiewicz-Kwedlo, Justyna Magdalena Hermanowicz, Tomasz Domaniewski, Krystyna Pawlak, Małgorzata Rusak, Anna Pryczynicz, Arkadiusz Surazynski, Tomasz Kaminski, Adam Kazberuk, Dariusz Pawlak

Br J Pharmacol. 2018 Mar;175(5):743-762.

PMID: 29160911

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