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Lithocholic acid

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For Research Use Only | Not For Clinical Use
CATAP434139-A
CAS434-13-9
Structure
MDL NumberMFCD00003682
Molecular Weight376.57
EC Number200-659-6
InChI KeySMEROWZSTRWXGI-HVATVPOCSA-N
REAXYS Number3217757
Description50 μg/mL in methanol, certified reference material
Gradecertified reference material
MP183-188 °C (lit.)
Size1ML
Storage Conditions−20°C
1

Development of Novel Lithocholic Acid Derivatives as Vitamin D Receptor Agonists

Hiroyuki Masuno, Yuko Kazui, Aya Tanatani, Shinya Fujii, Emiko Kawachi, Teikichi Ikura, Nobutoshi Ito, Keiko Yamamoto, Hiroyuki Kagechika

Bioorg Med Chem. 2019 Aug 15;27(16):3674-3681.

PMID: 31300316

1

Lithocholic Acid Activates mTOR Signaling Inducing Endoplasmic Reticulum Stress in Placenta During Intrahepatic Cholestasis of Pregnancy

Sheng Chao, Lin Xiaojun, Wang Haizhen, Fu Ludi, Liang Shaozhen, Su Zhiwen, Huang Weiliang, Jia Chunhong, Wang Ying, Wu Fan, Gao Yunfei

Life Sci. 2019 Feb 1;218:300-307.

PMID: 30605648

1

Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer

Patrik Kovács, Tamás Csonka, Tünde Kovács, Zsanett Sári, Gyula Ujlaki, Adrien Sipos, Zsolt Karányi, Dóra Szeőcs, Csaba Hegedűs, Karen Uray, Laura Jankó, Máté Kiss, Borbála Kiss, Damya Laoui, László Virág, etc.

Cancers (Basel). 2019 Aug 27;11(9):1255.

PMID: 31461945

1

Ursodeoxycholic Acid and Lithocholic Acid Exert Anti-Inflammatory Actions in the Colon

Joseph B J Ward, Natalia K Lajczak, Orlaith B Kelly, Aoife M O'Dwyer, Ashwini K Giddam, Joan Ní Gabhann, Placido Franco, Murtaza M Tambuwala, Caroline A Jefferies, Simon Keely, Aldo Roda, Stephen J Keely

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G550-G558.

PMID: 28360029

1

Vitamin E Analogues Differentially Inhibit Human Cytochrome P450 3A (CYP3A)-mediated Oxidative Metabolism of Lithocholic Acid: Impact of δ-tocotrienol on Lithocholic Acid Cytotoxicity

Siew Ying Wong, Josephine Si Min Teo, Swee Fen Chai, Szu Ling Yeap, Aik Jiang Lau

Toxicology. 2019 Jul 1;423:62-74.

PMID: 31102695

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