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LJI308

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For Research Use Only | Not For Clinical Use
CATAP1627709947
CAS1627709-94-7
MDL NumberMFCD29905461
Molecular Weight368.38
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Inhibition of RSK With the Novel Small-Molecule Inhibitor LJI308 Overcomes Chemoresistance by Eliminating Cancer Stem Cells

Alastair H Davies, Kristen Reipas, Kaiji Hu, Rachel Berns, Natalie Firmino, Anna L Stratford, Sandra E Dunn

Oncotarget. 2015 Aug 21;6(24):20570-7.

PMID: 26011941

1

Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-driven Cancers

Ida Aronchik, Brent A Appleton, Stephen E Basham, Kenneth Crawford, Mercedita Del Rosario, Laura V Doyle, William F Estacio, Jiong Lan, Mika K Lindvall, Catherine A Luu, Elizabeth Ornelas, Eleni Venetsanakos, etc.

Mol Cancer Res. 2014 May;12(5):803-12.

PMID: 24554780

1

Substituted Pteridinones as p90 Ribosomal S6 Protein Kinase (RSK) Inhibitors: A Structure-Activity Study

Kimberly A Casalvieri, Christopher J Matheson, Donald S Backos, Philip Reigan

Bioorg Med Chem. 2020 Mar 1;28(5):115303.

PMID: 31982240

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