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LLY-507

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For Research Use Only | Not For Clinical Use
CATIAR4243901
Molecular Weight574.76
InChI KeyPNYRDVBFYVDJJI-UHFFFAOYSA-N
Description≥97% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥97% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Comprehensive Study of Epigenetic Alterations in Hepatocellular Carcinoma Identifies Potential Therapeutic Targets

Juan Bayo, Esteban J Fiore, Luciana M Dominguez, Alejandrina Real, Mariana Malvicini, Manglio Rizzo, Catalina Atorrasagasti, Mariana G García, Josepmaria Argemi, Elisabeth D Martinez, Guillermo D Mazzolini

J Hepatol. 2019 Jul;71(1):78-90.

PMID: 30880225

1

Histone Methyltransferase SMYD2 Selective Inhibitor LLY-507 in Combination With Poly ADP Ribose Polymerase Inhibitor Has Therapeutic Potential Against High-Grade Serous Ovarian Carcinomas

Asako Kukita, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Masaaki Komatsu, Miku Wada, Harunori Honjoh, Yoshiko Kawata, Machiko Kojima, Shinya Oki, Masakazu Sato, Kayo Asada, Ayumi Taguchi, etc.

Biochem Biophys Res Commun. 2019 May 28;513(2):340-346.

PMID: 30955858

1

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2

Hannah Nguyen, Abdellah Allali-Hassani, Stephen Antonysamy, Shawn Chang, Lisa Hong Chen, Carmen Curtis, Spencer Emtage, Li Fan, Tarun Gheyi, Fengling Li, Shichong Liu, Joseph R Martin, David Mendel, Jonathan B Olsen, etc.

J Biol Chem. 2015 May 29;290(22):13641-53.

PMID: 25825497

1

Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics

Jonathan B Olsen, Xing-Jun Cao, Bomie Han, Lisa Hong Chen, Alexander Horvath, Timothy I Richardson, Robert M Campbell, Benjamin A Garcia, Hannah Nguyen

Mol Cell Proteomics. 2016 Mar;15(3):892-905.

PMID: 26750096

1

The Repositioning of Epigenetic probes/inhibitors Identifies New Anti-Schistosomal Lead Compounds and Chemotherapeutic Targets

Kezia C L Whatley, Gilda Padalino, Helen Whiteland, Kathrin K Geyer, Benjamin J Hulme, Iain W Chalmers, Josephine Forde-Thomas, Salvatore Ferla, Andrea Brancale, Karl F Hoffmann

PLoS Negl Trop Dis. 2019 Nov 15;13(11):e0007693.

PMID: 31730617

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