CAS 90719-30-5 Locostatin - Analytical Products / Alfa Chemistry

CAT	AP90719305
CAS	90719-30-5
Structure
MDL Number	MFCD00278769
Molecular Weight	245.27
InChI Key	UTZAFVPPWUIPBH-QSLRECBCSA-N

Description	≥98% (HPLC)
Solubility	DMSO: ≥30 mg/mL
Assay	≥98% (HPLC)
Color	white to off-white
Form	powder
Size	10MG, 50MG
Storage Conditions	2-8°C

1

Inhibition of the Raf-1 Kinase Inhibitory Protein (RKIP) by Locostatin Induces Cell Death and Reduces the CXCR4-mediated Migration of Chronic Lymphocytic Leukemia Cells

Kyle Crassini, Tahni Pyke, Yandong Shen, William S Stevenson, Richard I Christopherson, Stephen P Mulligan, Oliver Giles Best

Leuk Lymphoma. 2018 Dec;59(12):2917-2928.

PMID: 29911936

1

Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice

Junji Ma, Yuzi Qiu, Min Wang, Ming Zhang, Xiaoyi Zhao, Huiqing Jiang

Dig Dis Sci. 2019 Sep;64(9):2570-2580.

PMID: 30874989

1

Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket

Anwar B Beshir, Christian E Argueta, Lochana C Menikarachchi, José A Gascón, Gabriel Fenteany

For Immunopathol Dis Therap. 2011;2(1):47-58.

PMID: 21709760

1

Locostatin, a Disrupter of Raf Kinase Inhibitor Protein, Inhibits Extracellular Matrix Production, Proliferation, and Migration in Human Uterine Leiomyoma and Myometrial Cells

Milijana Janjusevic, Stefania Greco, Md Soriful Islam, Clara Castellucci, Andrea Ciavattini, Paolo Toti, Felice Petraglia, Pasquapina Ciarmela

Fertil Steril. 2016 Nov;106(6):1530-1538.e1.

PMID: 27565262

1

Raf Kinase Inhibitory Protein Protects Cells Against Locostatin-Mediated Inhibition of Migration

Anne N Shemon, Eva M Eves, Matthew C Clark, Gary Heil, Alexey Granovsky, Lingchun Zeng, Akira Imamoto, Shohei Koide, Marsha Rich Rosner

PLoS One. 2009 Jun 24;4(6):e6028.

PMID: 19551145

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