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Lomeguatrib

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For Research Use Only | Not For Clinical Use
CATAP192441080
CAS192441-08-0
Structure
MDL NumberMFCD23703756
Molecular Weight326.17
InChI KeyJUJPKFNFCWJBCX-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

A Phase I Study of Extended Dosing With Lomeguatrib With Temozolomide in Patients With Advanced Melanoma

R F Kefford, N P B Thomas, P G Corrie, C Palmer, E Abdi, D Kotasek, J Beith, M Ranson, P Mortimer, A J Watson, G P Margison, M R Middleton

Br J Cancer. 2009 Apr 21;100(8):1245-9.

PMID: 19367282

1

Effect of Lomeguatrib-Temozolomide Combination on MGMT Promoter Methylation and Expression in Primary Glioblastoma Tumor Cells

Mehmet Taspinar, Seda Ilgaz, Mevci Ozdemir, Tulin Ozkan, Derya Oztuna, Hande Canpinar, Juan A Rey, Asuman Sunguroğlu, Javier S Castresana, Hasan Caglar Ugur

Tumour Biol. 2013 Jun;34(3):1935-47.

PMID: 23519841

1

Lomeguatrib, a Potent Inhibitor of O6-alkylguanine-DNA-alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination With Temozolomide in Patients With Advanced Solid Tumors

Malcolm Ranson, Mark R Middleton, John Bridgewater, Siow Ming Lee, Martin Dawson, Debra Jowle, Gavin Halbert, Sue Waller, Helen McGrath, Lindsey Gumbrell, R Stanley McElhinney, Dorothy Donnelly, T Brian H McMurry, etc.

Clin Cancer Res. 2006 Mar 1;12(5):1577-84.

PMID: 16533784

1

Preparation of PEGylated Liposomes Incorporating Lipophilic Lomeguatrib Derivatives for the Sensitization of Chemo-Resistant Gliomas

Rea D Signorell, Alexandros Papachristodoulou, Jiawen Xiao, Bianca Arpagaus, Tommaso Casalini, Joanes Grandjean, Jana Thamm, Frank Steiniger, Paola Luciani, Davide Brambilla, Beat Werner, Ernst Martin, etc.

Int J Pharm. 2018 Jan 30;536(1):388-396.

PMID: 29198811

1

Temozolomide: Mechanisms of Action, Repair and Resistance

Jihong Zhang, Malcolm F G Stevens, Tracey D Bradshaw

Curr Mol Pharmacol. 2012 Jan;5(1):102-14.

PMID: 22122467

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