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Lorlatinib

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For Research Use Only | Not For Clinical Use
CATAP1454846355-A
CAS1454846-35-5 (free base)
MDL NumberMFCD28144520
Molecular Weight406.41
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

ALK Resistance Mutations and Efficacy of Lorlatinib in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer

Alice T Shaw, Benjamin J Solomon, Benjamin Besse, Todd M Bauer, Chia-Chi Lin, Ross A Soo, Gregory J Riely, Sai-Hong Ignatius Ou, Jill S Clancy, Sherry Li, Antonello Abbattista, Holger Thurm, Miyako Satouchi, etc.

J Clin Oncol. 2019 Jun 1;37(16):1370-1379.

PMID: 30892989

1

Clinical Management of Adverse Events Associated With Lorlatinib

Todd M Bauer, Enriqueta Felip, Benjamin J Solomon, Holger Thurm, Gerson Peltz, Marc D Chioda, Alice T Shaw

Oncologist. 2019 Aug;24(8):1103-1110.

PMID: 30890623

1

Lorlatinib in Non-Small-Cell Lung Cancer With ALK or ROS1 Rearrangement: An International, Multicentre, Open-Label, Single-Arm First-In-Man Phase 1 Trial

Alice T Shaw, Enriqueta Felip, Todd M Bauer, Benjamin Besse, Alejandro Navarro, Sophie Postel-Vinay, Justin F Gainor, Melissa Johnson, Jorg Dietrich, Leonard P James, Jill S Clancy, Joseph Chen, Jean-François Martini, etc.

Lancet Oncol. 2017 Dec;18(12):1590-1599.

PMID: 29074098

1

Lorlatinib in Patients With ALK-positive Non-Small-Cell Lung Cancer: Results From a Global Phase 2 Study

Benjamin J Solomon, Benjamin Besse, Todd M Bauer, Enriqueta Felip, Ross A Soo, D Ross Camidge, Rita Chiari, Alessandra Bearz, Chia-Chi Lin, Shirish M Gadgeel, Gregory J Riely, Eng Huat Tan, Takashi Seto, etc.

Lancet Oncol. 2018 Dec;19(12):1654-1667.

PMID: 30413378

1

Molecular Mechanisms of Resistance to First- And Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer

Justin F Gainor, Leila Dardaei, Satoshi Yoda, Luc Friboulet, Ignaty Leshchiner, Ryohei Katayama, Ibiayi Dagogo-Jack, Shirish Gadgeel, Katherine Schultz, Manrose Singh, Emily Chin, Melissa Parks, Dana Lee, etc.

Cancer Discov. 2016 Oct;6(10):1118-1133.

PMID: 27432227

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