CAS 209984-57-6 LY-411575 - Analytical Products / Alfa Chemistry

CAT	AP209984576
CAS	209984-57-6
Structure
MDL Number	MFCD09832551
Molecular Weight	479.48
InChI Key	ULSSJYNJIZWPSB-CVRXJBIPSA-N

Description	≥97% (HPLC)
Solubility	DMSO: 5 mg/mL, clear
Assay	≥97% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

Critical Role of Soluble amyloid-β for Early Hippocampal Hyperactivity in a Mouse Model of Alzheimer's Disease

Marc Aurel Busche, Xiaowei Chen, Horst A Henning, Julia Reichwald, Matthias Staufenbiel, Bert Sakmann, Arthur Konnerth

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8740-5.

PMID: 22592800

1

Existing Plaques and Neuritic Abnormalities in APP:PS1 Mice Are Not Affected by Administration of the Gamma-Secretase Inhibitor LY-411575

Monica Garcia-Alloza, Meenakshi Subramanian, Diana Thyssen, Laura A Borrelli, Abdul Fauq, Pritam Das, Todd E Golde, Bradley T Hyman, Brian J Bacskai

Mol Neurodegener. 2009 May 6;4:19.

PMID: 19419556

1

Quantitative Measurement of Changes in amyloid-beta(40) in the Rat Brain and Cerebrospinal Fluid Following Treatment With the Gamma-Secretase Inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]

Jonathan D Best, Mark T Jay, Franklin Otu, Jerome Ma, Alan Nadin, Semantha Ellis, Huw D Lewis, Christine Pattison, Michael Reilly, Timothy Harrison, Mark S Shearman, Toni L Williamson, John R Atack

J Pharmacol Exp Ther. 2005 May;313(2):902-8.

PMID: 15743924

1

Reducing Available Soluble β-amyloid Prevents Progression of Cerebral Amyloid Angiopathy in Transgenic Mice

Julia L Gregory, Claudia M Prada, Sara J Fine, Monica Garcia-Alloza, Rebecca A Betensky, Michal Arbel-Ornath, Steven M Greenberg, Brian J Bacskai, Matthew P Frosch

J Neuropathol Exp Neurol. 2012 Nov;71(11):1009-17.

PMID: 23095848

1

Studies of Abeta Pharmacodynamics in the Brain, Cerebrospinal Fluid, and Plasma in Young (Plaque-Free) Tg2576 Mice Using the Gamma-Secretase Inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575)

Thomas A Lanz, John D Hosley, Wade J Adams, Kalpana M Merchant

J Pharmacol Exp Ther. 2004 Apr;309(1):49-55.

PMID: 14718585

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