LY2033298 - Analytical Products / Alfa Chemistry

CAT	IAR4241553
MDL Number	MFCD12912423
Molecular Weight	311.79
InChI Key	CTEGQKDJTBWFHW-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: >20 mg/mL
Assay	≥98% (HPLC)
Color	off-white to tan
Form	solid
Size	5MG, 25MG
Storage Conditions	−20°C

1

Cholinergic M 4 receptors are involved in morphine-induced expression of behavioral sensitization by regulating dopamine function in the nucleus accumbens of rats

Heng Ruan, Jinling Sun, Xinhe Liu, Liyuan Liu, Ruisi Cui, Xinwang Li

Behav Brain Res. 2019 Mar 15;360:128-133.

PMID: 30529589

1

Development of a Radioligand, [(3)H]LY2119620, to Probe the Human M(2) and M(4) Muscarinic Receptor Allosteric Binding Sites

Douglas A Schober, Carrie H Croy, Hongling Xiao, Arthur Christopoulos, Christian C Felder

Mol Pharmacol. 2014 Jul;86(1):116-23.

PMID: 24807966

1

Impact of Species Variability and 'Probe-Dependence' on the Detection and in Vivo Validation of Allosteric Modulation at the M4 Muscarinic Acetylcholine Receptor

S Suratman, K Leach, Pm Sexton, Cc Felder, Re Loiacono, A Christopoulos

Br J Pharmacol. 2011 Apr;162(7):1659-70.

PMID: 21198541

1

Molecular Mechanisms of Action and in Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator With Potential Antipsychotic Properties

Katie Leach, Richard E Loiacono, Christian C Felder, David L McKinzie, Adrian Mogg, David B Shaw, Patrick M Sexton, Arthur Christopoulos

Neuropsychopharmacology. 2010 Mar;35(4):855-69.

PMID: 19940843

1

New Insights Into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

Vindhya Nawaratne, Katie Leach, Nur Suratman, Richard E Loiacono, Christian C Felder, Blaine N Armbruster, Bryan L Roth, Patrick M Sexton, Arthur Christopoulos

Mol Pharmacol. 2008 Oct;74(4):1119-31.

PMID: 18628403

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