CAS 69-65-8 Mannitol - Analytical Products / Alfa Chemistry

CAT	APS69658
CAS	69-65-8
Structure
MDL Number	MFCD00064287
Synonyms	Osmitrol, Pearlitol 100, Mannitol 60, Bronchitol, Mannit S, Mannitol 35, D-Mannitol, Manicol, Resectisol, Cordycepic acid (6CI,7CI), Partek M, d-Mannitol, Parteck 300, PharmMannidex 16701, Mannit P, Mannitol P 60, Pearlitol 100SD, Mannidex 16700, Nonpareil 108, Nonpareil 108(200), Mannitolum, Pearlitol, Parteck M 200, Maniton S, Pearlitol 50C, Mannitol, D- (8CI), Mannitol SD 200, Orocell 200, Brightmoon, Cerestar 16700, E 421, Pearlitol 160C, Parteck M 100, Osmosal, Parteck Delta M, D-(-)-Mannitol, Mannidex, Parteck M 300, Mannistol, Mannogem 2080, Mannit,Mannitol, Pearlitol 200SD, Perteck M, Pearlitol 2005D, Manna sugar, Mannite, Isotol, D-Mannit, Perlitol SD 200, Mannigen, Diosmol, Pearlitol SD 100, Pearlitol 25C, PharmMannidex, Mannogem EZ, Mannit 60, Marine Crystal
IUPAC Name	(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Molecular Weight	182.17
Molecular Formula	C6H14O6
EC Number	200-711-8
Canonical SMILES	OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI	InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChI Key	FBPFZTCFMRRESA-KVTDHHQDSA-N
REAXYS Number	1721898

Description	United States Pharmacopeia (USP) Reference Standard
Accurate Mass	182.079
Form	neat
Format	Neat
MP	167-170 °C (lit.)
Size	1.5G

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CAT	Size	Shipping	Storage Conditions	Description	Price
APS69658-1200MG	1200MG	Room Temperature	2-8°C Fridge/Coldroom	API Family: Matrix - API Family See respective official monograph(s); Product Type: Excipient; Subcategory: British Pharmacopoeia	Inquiry
APS69658-250MG	250MG	Room Temperature	+5°C	API Family: Matrix - API Family Mannitol; Sorbitol; myo-Inositol; Lactitol Monohydrate; Product Type: API/ Impurity; Subcategory: Respiratory drugs, API standards, Impurity standards, Vitamins and derivatives, Mikromol	Inquiry

Case Study

Mannitol Used for the Functionalization of Magnetic Nanoparticles in the Microextraction and Fluorometric Detection of Carmine (E120) Dye

Aburub, Samer S., et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 327 (2025): 125380.

In this study, mannitol was employed to functionalize magnetic nanoparticles (MMNPs) via a modified co-precipitation route, enabling efficient adsorption of the polar food dye carmine (E120) through electrostatic interactions. The synthesized mannitol-functionalized magnetic nanoparticles (MMNPs) acted as a selective nanosorbent in dispersive micro-solid-phase extraction (Dµ-SPE) of E120 from juice and water matrices.
The functionalization process involved co-precipitating FeCl₂·4H₂O and FeCl₃·6H₂O in deionized water at 70 °C, followed by the addition of NH₃ to induce nanoparticle formation. D-mannitol (1000 mg) was then introduced at 90 °C to covalently bind onto the surface, enhancing hydrophilicity and interaction with the dye molecules. The MMNPs were magnetically separated, washed, and dried, yielding stable, reusable sorbents with high adsorption capacity (87.7 mg·g⁻¹).
Post-extraction, E120 was quantified fluorometrically using nitrogen-doped carbon dots (N-CDs) via an inner filter effect (IFE) mechanism. The method achieved a wide linear range (1.0-160.0 μg·mL⁻¹) with low detection (0.27 μg·mL⁻¹) and quantification limits (0.83 μg·mL⁻¹). The approach demonstrated high reproducibility (%RSD < 2.34%) and excellent recovery (89.2-107.2%) in complex samples.
This work underscores the utility of mannitol as a green, biocompatible ligand in nanoparticle engineering for analytical and environmental applications, particularly for detecting food additives in complex aqueous media.

Mannitol Used for the Co-Processing of HPMC in Direct Compression Controlled Release Formulations

Kang, Christina Yong Xin, et al. International journal of pharmaceutics 660 (2024): 124298.

Mannitol plays a pivotal role in enhancing the manufacturability of controlled-release (CR) oral drug formulations through co-processing with hydroxypropyl methylcellulose (HPMC). In this study, mannitol syrup was spray-coated onto fluidized HPMC particles to prepare co-processed HPMC-mannitol excipients at varying ratios (20:80, 50:50, 70:30). These engineered excipients were evaluated for their powder flow characteristics, compaction properties, and drug release behavior.
Compared to pure HPMC, the co-processed HPMC-mannitol particles demonstrated significantly improved flowability, a critical property for direct compression. Tablets formed with these composites maintained tensile strengths >2 MPa under moderate to high compression forces (150-200 MPa), meeting mechanical robustness requirements. The release kinetics could be fine-tuned by adjusting the HPMC-to-mannitol ratio, offering formulation flexibility.
Notably, the H70M30-CP grade performed comparably to commercial HPMC DC in high drug load formulations (up to 50% w/w), accommodating a wide solubility range (10-186 mg/mL) without compromising release profiles. This variant was subsequently developed into the commercial excipient "mannitol CR-H," which successfully mimicked the release performance of marketed propranolol and metformin tablets.
Overall, mannitol, when co-processed with HPMC, addresses the inherent flow limitations of HPMC while preserving controlled-release capabilities. Its application in CR-H grade excipients underscores its utility in robust, directly compressible matrix systems for modern oral solid dosage forms.

Mannitol Used for the Biosynthesis of 2'-Fucosyllactose via Yarrowia lipolytica Fermentation

Zhang, Yan, et al. Bioresource Technology (2025): 132583.

Mannitol, a naturally abundant sugar alcohol derived from marine biomass, has been demonstrated as an effective carbon source for microbial biosynthesis. In this study, mannitol was utilized by Yarrowia lipolytica as a key substrate for the efficient production of 2'-fucosyllactose (2'-FL), an important human milk oligosaccharide. Compared with glucose, mannitol in combination with lactose significantly enhanced both cell growth and 2'-FL titer.
Transcriptomic analysis revealed that endogenous hexose transporters Yht1 and Yht3 play pivotal roles in mannitol uptake. By engineering these transporters and optimizing the GDP-D-mannose synthesis pathway, a recombinant Y. lipolytica strain was developed, achieving 2'-FL titers of 9 g/L in shake flask culture. Fed-batch fermentation in an inorganic salt medium supplemented with mannitol and lactose further increased production to 27.6 g/L.
Detailed process optimization involved use of YPM and CM1 media with mannitol concentrations ranging from 60-75 g/L, and controlled feeding (30-65 g/L) during depletion phases. Notably, mannitol-rich brown algae processing wastewater (44 g/L mannitol) supported comparable growth and product formation, demonstrating the potential of waste valorization in industrial biomanufacturing.
This work highlights mannitol's dual value as a renewable substrate and fermentation enhancer for 2'-FL biosynthesis, offering a sustainable route to functional oligosaccharides and expanding the biotechnological use of marine-derived carbohydrates.