CAS 1227962-62-0 (±)-Marinopyrrole A - Analytical Products / Alfa Chemistry

CAT	AP1227962620
CAS	1227962-62-0
Molecular Weight	510.15

Description	≥95% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥95% (HPLC)
Color	light yellow to dark yellow
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

De-orphaning the Marine Natural Product (±)-marinopyrrole A by Computational Target Prediction and Biochemical Validation

P Schneider, G Schneider

Chem Commun (Camb). 2017 Feb 14;53(14):2272-2274.

PMID: 28154844

1

Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist That Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

Kenichiro Doi, Rongshi Li, Shen-Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, etc.

J Biol Chem. 2012 Mar 23;287(13):10224-35.

PMID: 22311987

1

Purported Mcl-1 Inhibitor Marinopyrrole A Fails to Show Selective Cytotoxicity for Mcl-1-dependent Cell Lines

J M Eichhorn, S E Alford, C C Hughes, W Fenical, T C Chambers

Cell Death Dis. 2013 Oct 24;4(10):e880.

PMID: 24157874

1

The Selectivity of Marinopyrrole A to Induce Apoptosis in MCL1

Patricia Gomez-Bougie, Christelle Dousset, Geraldine Descamps, Anne Schnitzler, Logan Audiger, Arnaud Tessier, Didier Dubreuil, Jacques Lebreton, Catherine Pellat-Deceunynck, Martine Amiot

Br J Haematol. 2018 Jan;180(1):157-159.

PMID: 27523575

1

Total Synthesis of (±)-marinopyrrole A via Copper-Mediated N-arylation

Argyrios A Kanakis, Vasiliki Sarli

Org Lett. 2010 Nov 5;12(21):4872-5.

PMID: 20886840

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