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Meropenem trihydrate

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For Research Use Only | Not For Clinical Use
CATAP119478567-A
CAS119478-56-7
Structure
MDL NumberMFCD08600005
Synonyms(4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate,Meropenem trihydrate, [4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate, (4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]pyrrolidin-3-yl]sulfanyl]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate, (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate
IUPAC Name(4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate
Molecular Weight437.51
Molecular FormulaC17H25N3O5S.3H2O
Canonical SMILESO.O.O.C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(=C(N2C1=O)C(=O)O)S[C@@H]3CN[C@@H](C3)C(=O)N(C)C
InChIInChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1
InChI KeyCTUAQTBUVLKNDJ-OBZXMJSBSA-N
Descriptionanalytical standard, ≥98% (HPLC)
SolubilityDMSO: ≥20 mg/mL
Accurate Mass437.1832
Assay≥98% (HPLC)
Colorwhite to off-white
Formneat; gas chromatography (GC): suitable; powder
FormatNeat
Gradeanalytical standard
Size10MG, 25MG, 50MG
Storage Conditions-20°C
1

An Investigation of the Stability of Meropenem in Elastomeric Infusion Devices

Finbarr Foy, Giuseppe Luna, Jorge Martinez, Zach Nizich, Jason Seet, Katie Lie, Bruce Sunderland, Petra Czarniak

Drug Des Devel Ther. 2019 Aug 1;13:2655-2665.

PMID: 31447546

1

Delafloxacin Meglumine, Meropenem trihydrate/vaborbactam, Secnidazole, and Benznidazole

Daniel A Hussar, Molly A Walter

J Am Pharm Assoc (2003). Mar-Apr 2018;58(2):223-227.

PMID: 29506662

1

Impact of Antibacterial Drugs on Human Serum paraoxonase-1 (hPON1) Activity: An in Vitro Study

Hakan Söyüt, Elif Duygu Kaya, Sükrü Beydemir

Asian Pac J Trop Biomed. 2014 Aug;4(8):603-9.

PMID: 25183328

1

MALDI-TOF MS Applied to Indirect Carbapenemase Detection: A Validated Procedure to Clearly Distinguish Between Carbapenemase-Positive and Carbapenemase-Negative Bacterial Strains

Lijun Wang, Chao Han, Wenjun Sui, Mei Wang, Xinxin Lu

Anal Bioanal Chem. 2013 Jun;405(15):5259-66.

PMID: 23584712

1

The Radiostability of Meropenem Trihydrate in Solid State

Karolina Kilińska, Judyta Cielecka-Piontek, Robert Skibiński, Daria Szymanowska, Andrzej Miklaszewski, Waldemar Bednarski, Ewa Tykarska, Anna Stasiłowicz, Przemysław Zalewski

Molecules. 2018 Oct 23;23(11):2738.

PMID: 30360551

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