Metastin (45-54) - Analytical Products / Alfa Chemistry

CAT	IAR4249363
Molecular Weight	1302.44

Description	A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).
Solubility	DMSO: 5 mg/mL
Assay	≥97% (HPLC)
Color	white
Form	lyophilized solid; desiccated
Size	1MG
Storage Conditions	-20C

1

Continuous Human Metastin 45-54 Infusion Desensitizes G Protein-Coupled Receptor 54-induced Gonadotropin-Releasing Hormone Release Monitored Indirectly in the Juvenile Male Rhesus Monkey (Macaca Mulatta): A Finding With Therapeutic Implications

Stephanie B Seminara, Meloni J Dipietro, Suresh Ramaswamy, William F Crowley Jr, Tony M Plant

Endocrinology. 2006 May;147(5):2122-6.

PMID: 16469799

1

Design and Synthesis of Downsized Metastin (45-54) Analogs With Maintenance of High GPR54 Agonistic Activity

Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R Broach, Stephen C Peiper, Nobutaka Fujii

Bioorg Med Chem Lett. 2006 Jan 1;16(1):134-7.

PMID: 16242330

1

Design, Synthesis, and Biological Evaluation of Novel Investigational Nonapeptide KISS1R Agonists With Testosterone-Suppressive Activity

Taiji Asami, Naoki Nishizawa, Hisanori Matsui, Kimiko Nishibori, Yoshihiro Ishibashi, Yasuko Horikoshi, Masaharu Nakayama, Shin-ichi Matsumoto, Naoki Tarui, Masashi Yamaguchi, Hirokazu Matsumoto, Tetsuya Ohtaki, etc.

J Med Chem. 2013 Nov 14;56(21):8298-307.

PMID: 24047141

1

Effect of Continuous Intravenous Administration of Human Metastin 45-54 on the Neuroendocrine Activity of the Hypothalamic-Pituitary-Testicular Axis in the Adult Male Rhesus Monkey (Macaca Mulatta)

Suresh Ramaswamy, Stephanie B Seminara, Clifford R Pohl, Meloni J DiPietro, William F Crowley Jr, Tony M Plant

Endocrinology. 2007 Jul;148(7):3364-70.

PMID: 17412800

1

Trypsin Resistance of a Decapeptide KISS1R Agonist Containing an Nω-methylarginine Substitution

Taiji Asami, Naoki Nishizawa, Yoshihiro Ishibashi, Kimiko Nishibori, Yasuko Horikoshi, Hirokazu Matsumoto, Tetsuya Ohtaki, Chieko Kitada

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6328-32.

PMID: 22995619

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