CAS 9004-67-5 Methyl cellulose - Analytical Products / Alfa Chemistry

CAT	AP9004675
CAS	9004-67-5
Structure
MDL Number	MFCD00081763

Effects of Montmorillonite on Properties of Methyl cellulose/carvacrol Based Active Antimicrobial Nanocomposites

Sibel Tunç, Osman Duman, Tülin Gürkan Polat

Carbohydr Polym. 2016 Oct 5;150:259-68.

PMID: 27312637

Evaluation of Properties of Mineral Trioxide Aggregate With Methyl Cellulose as Liquid

Omid Dianat, Mandana Naseri, Seyedeh Farnaz Tabatabaei

J Dent (Tehran). 2017 Jan;14(1):7-12.

PMID: 28828012

Functional Cellulose-Based Hydrogels as Extracellular Matrices for Tissue Engineering

Sayan Deb Dutta, Dinesh K Patel, Ki-Taek Lim

J Biol Eng. 2019 Jun 20;13:55.

PMID: 31249615

Methyl-cellulose Powder for Prevention and Management of Nasal Symptoms

Todor A Popov, Nils Åberg, Jean Emberlin, Peter Josling, Natalia I Ilyina, Nikolai P Nikitin, Martin Church

Expert Rev Respir Med. 2017 Nov;11(11):885-892.

PMID: 28862062

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters

Hale Cigdem Arca, Laura I Mosquera-Giraldo, Vivian Bi, Daiqiang Xu, Lynne S Taylor, Kevin J Edgar

Biomacromolecules. 2018 Jul 9;19(7):2351-2376.

PMID: 29869877

* Products or Services Interested: Methyl cellulose (9004-67-5)
* Your question
* Name
* Email
Verification Code

CAT	Size	Description	Price
AP9004675-1	1G	United States Pharmacopeia (USP) Reference Standard	Inquiry
AP9004675-2	500G	tested according to Ph Eur	Inquiry

Case Study

Methyl Cellulose for the Preparation of Biocomposite Hydrogels in Drug Delivery Systems

Islam, Md Monirul, and Md Ibrahim H. Mondal. International Journal of Biological Macromolecules (2025): 146795.

Methyl cellulose (MC) serves as a versatile polymeric base for developing biocomposite hydrogels with biomedical applications. A recent study explored the incorporation of polyvinyl pyrrolidone (PVP) and quercetin (QC) into an MC hydrogel network to achieve controlled drug release with antibacterial and antioxidant activity. The preparation procedure was systematically designed as follows:
1. MC Gel Preparation: A 5 % (w/v) MC solution was dispersed in 0.05 M Na₂SO₄ saline, heated to 55 °C, cooled to 25 °C, and stored at 4 °C for full hydration. The pH was adjusted to 10 using 1 M NaOH.
2. Crosslinking Step: Citric acid (CA) was introduced at a 1:20 (w/w) ratio, and the mixture was heated to 190 °C for 15 min, forming covalent crosslinks between MC chains.
3. Composite Formation: The crosslinked MC solution was blended with 5 % (w/v) PVP in a 4:1 (v/v) ratio, with sorbitol added (0.25 mL per gram of polymer) to enhance malleability. The suspension was homogenized ultrasonically for 15 min.
4. Film Casting and Drug Loading: The MC/PVP mixture was cast into Petri dishes, air-dried for 72 h, and subsequently freeze-dried to form porous hydrogel films. QC suspensions (2-6 wt%) were then incorporated into the matrix to obtain MC/PVP/QC hydrogels.
The resulting biocomposite exhibited high swelling capacity (940 % at pH 7.4), excellent drug loading (94.06 ± 5.56 %), and sustained release (82 % at pH 7.4 over 72 h), making MC-based hydrogels effective carriers for wound healing and topical drug delivery.

Methyl Cellulose for the Preparation of WO₃-Based Photochromic Composite Films

Lee, Ki-Won, Myeong-Hun Jo, and Hyo-Jin Ahn. Surfaces and Interfaces 59 (2025): 105976.

Methyl cellulose (MC), a versatile cellulose derivative, has emerged as a critical additive in enhancing the performance of photochromic (PC) materials. A recent study demonstrated its role in the preparation of WO₃/methyl cellulose (WO₃/MC) composite films, which exhibited improved photochromic switching kinetics through the incorporation of WO₃ quantum dots (WQDs).
The fabrication procedure followed a systematic approach:
1. WO₃/MC Precursor Formation: 0.6 g WO₃ precursor, 0.8 g MC, and 2.34 mL ethylene glycol were dissolved in 45 mL deionized water, stirred for 1 h, and sonicated for 1.5 h.
2. WQD Solution Preparation: 0.6 g WQDs were dispersed in 10 mL deionized water using a homogenizer, then filtered through a syringe pump.
3. Composite Integration: The WQD solution was introduced into the WO₃/MC precursor mixture (with 35 mL deionized water), ensuring uniform dispersion.
4. Film Casting and Assembly: 8 mL of precursor solution was cast into Petri dishes, dried at 50 °C for 24 h, and peeled into 2 × 2.5 cm² films, which were then assembled between fluorine-doped tin oxide substrates.
MC not only acted as a structural binder but also engaged in chemical crosslinking with WQDs, introducing sp² C-C interactions. These linkages provided new electron transfer pathways and defect states, accelerating bleaching by 60.5 min compared to bare WO₃.
This case underscores methyl cellulose as a functional polymer for fabricating high-performance photochromic films, offering enhanced electron dynamics and faster switching for next-generation optical devices.

Methyl Cellulose for the Preparation of Catalytic Polyvinyl Alcohol Composite Membranes in Dye Degradation Applications

Wu, Zhichen, et al. Materials Chemistry and Physics 345 (2025): 131143.

Methyl cellulose (MC), a hydrophilic cellulose derivative, plays a pivotal role in fabricating catalytic membranes for advanced oxidation processes (AOPs). In a recent study, MC was combined with polyvinyl alcohol (PVA) to construct composite membranes embedded with cobalt/sulfur (Co/S) co-doped carbon-based catalysts for the degradation of methylene blue (MB).
The preparation method was systematically designed as follows:
1. Polymer Solution Preparation: 2 wt% MC and 10 wt% PVA solutions were prepared separately.
2. Blending and Ratio Optimization: The solutions were mixed at varying PVA:MC ratios (3:7, 4:6, 5:5, 10:0), stirred for 3 h, and vacuum-defoamed.
3. Membrane Casting: The mixtures were coated onto PTFE sheets, pre-cured at 80 °C for 20 min, then fully cured at 130 °C for 2 h.
4. Catalyst Loading: Co/S co-doped catalysts (1-5 mg/mL) were dispersed into the polymer mixtures, followed by the same curing protocol to yield catalytic membranes.
The optimal composition, P4 (PVA:MC = 4:6), displayed superior water flux (954 L/m²h), swelling capacity (221.9 %), and elongation at break (2.02 %). Importantly, P4 achieved >99.5 % MB degradation within 10 min over three cycles, outperforming other ratios where excessive PVA or MC induced unilateral intramolecular crosslinking, reducing uniformity and strength.
This case demonstrates that methyl cellulose is not only a structural matrix but also a key regulator of crosslinking balance, membrane morphology, and catalytic performance, making it indispensable in the design of high-efficiency AOP membranes for wastewater treatment.