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MKT-077

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For Research Use Only | Not For Clinical Use
CATAP147366414
CAS147366-41-4
MDL NumberMFCD27665468
Molecular Weight432.00
InChI KeyVSKYOTRJSLYFHX-UXJRWBAGSA-M
Description≥98% (HPLC), powder
SolubilityH2O: 10 mg/mL, clear
Assay≥98% (HPLC)
Colororange to red
Formpowder
Linear FormulaC21H22N3OS2Cl
Size5MG, 25MG
Storage Conditions2-8°C
1

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 With Human Hsp70 Chaperones

Aikaterini Rousaki, Yoshinari Miyata, Umesh K Jinwal, Chad A Dickey, Jason E Gestwicki, Erik R P Zuiderweg

J Mol Biol. 2011 Aug 19;411(3):614-32.

PMID: 21708173

1

In Vivo Administration of MKT-077 Causes Partial Yet Reversible Impairment of Mitochondrial Function

E L Weisberg, K Koya, J Modica-Napolitano, Y Li, L B Chen

Cancer Res. 1996 Feb 1;56(3):551-5.

PMID: 8564970

1

Rhodacyanine Dye MKT-077 Inhibits in Vitro Telomerase Assay but Has No Detectable Effects on Telomerase Activity in Vivo

Renu Wadhwa, Lorel Colgin, Tomoko Yaguchi, Kazunari Taira, Roger R Reddel, Sunil C Kaul

Cancer Res. 2002 Aug 1;62(15):4434-8.

PMID: 12154051

1

Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo

Dmytro Starenki, Jong In Park

Endocrinol Metab (Seoul). 2015 Dec;30(4):593-603.

PMID: 26485469

1

Uptake Rate of Cationic Mitochondrial Inhibitor MKT-077 Determines Cellular Oxygen Consumption Change in Carcinoma Cells

John L Chunta, Kerry S Vistisen, Zeinab Yazdi, Rod D Braun

PLoS One. 2012;7(5):e37471.

PMID: 22616013

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