CAS 1222878-02-5 ML169 - Analytical Products / Alfa Chemistry

CAT	AP1222878025
CAS	1222878-02-5
MDL Number	MFCD23704785
Molecular Weight	506.34
InChI Key	RUYRNYRGPSAXTK-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: >5 mg/mL
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Discovery and Development of a Second Highly Selective M

Thomas M Bridges, Paul R Reid, L Michelle Lewis, Eric S Dawson, C David Weaver, Michael R Wood, Craig W Lindsley

PMID: 21433394

1

Discovery and Optimization of a Novel, Selective and Brain Penetrant M1 Positive Allosteric Modulator (PAM): The Development of ML169, an MLPCN Probe

Paul R Reid, Thomas M Bridges, Douglas J Sheffler, Hyekyung P Cho, L Michelle Lewis, Emily Days, J Scott Daniels, Carrie K Jones, Colleen M Niswender, C David Weaver, P Jeffrey Conn, Craig W Lindsley, Michael R Wood

Bioorg Med Chem Lett. 2011 May 1;21(9):2697-701.

PMID: 21194936

1

Left Ventricular Dilation and Functional Impairment Assessed by Gated SPECT Are Indicators of Cardiac Allograft Vasculopathy in Heart Transplant Recipients

Christian Wenning, Jörg Stypmann, Philipp Papavassilis, Jürgen Sindermann, Otmar Schober, Andreas Hoffmeier, Hans H Scheld, Lars Stegger, Michael Schäfers

J Heart Lung Transplant. 2012 Jul;31(7):719-28.

PMID: 22425234

1

Targeting Selective Activation of M(1) for the Treatment of Alzheimer's Disease: Further Chemical Optimization and Pharmacological Characterization of the M(1) Positive Allosteric Modulator ML169

James C Tarr, Mark L Turlington, Paul R Reid, Thomas J Utley, Douglas J Sheffler, Hyekyung P Cho, Rebecca Klar, Tristano Pancani, Michael T Klein, Thomas M Bridges, Ryan D Morrison, Anna L Blobaum, Zixui Xiang, etc.

ACS Chem Neurosci. 2012 Nov 21;3(11):884-95.

PMID: 23173069

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