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ML216

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For Research Use Only | Not For Clinical Use
CATIAR4244075
Molecular Weight383.32
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorlight orange to dark orange
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

Giang Huong Nguyen, Thomas S Dexheimer, Andrew S Rosenthal, Wai Kit Chu, Dharmendra Kumar Singh, Georgina Mosedale, Csanád Z Bachrati, Lena Schultz, Masaaki Sakurai, Pavel Savitsky, Mika Abu, Peter J McHugh, etc.

Chem Biol. 2013 Jan 24;20(1):55-62.

PMID: 23352139

1

Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase

Andrew S. Rosenthal, Thomas S. Dexheimer, G Nguyen, Opher Gileadi, Alessandro Vindigni, Anton Simeonov, Ajit Jadhav, Ian Hickson, David J. Maloney

PMID: 24027802

1

Generation of Targeted Homozygosity in the Genome of Human Induced Pluripotent Stem Cells

Yasuhide Yoshimura, Ayako Yamanishi, Tomo Kamitani, Jin-Soo Kim, Junji Takeda

PLoS One. 2019 Dec 5;14(12):e0225740.

PMID: 31805151

1

Genetic Mapping of Species Differences via in Vitro Crosses in Mouse Embryonic Stem Cells

Stefano Lazzarano, Marek Kučka, João P L Castro, Ronald Naumann, Paloma Medina, Michael N C Fletcher, Rebecka Wombacher, Joost Gribnau, Tino Hochepied, Marc Van Montagu, Claude Libert, Yingguang Frank Chan

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3680-3685.

PMID: 29563231

1

Synthesis and SAR Studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine Derivatives as Potent Inhibitors of Bloom Helicase

Andrew S Rosenthal, Thomas S Dexheimer, Opher Gileadi, Giang H Nguyen, Wai Kit Chu, Ian D Hickson, Ajit Jadhav, Anton Simeonov, David J Maloney

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6.

PMID: 24012121

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