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ML218

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For Research Use Only | Not For Clinical Use
CATAP1346233688
CAS1346233-68-8
Molecular Weight369.33
InChI KeyGSJIGYLGKSBYBC-OSYLJGHBSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL (clear solution)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Anatomical Localization of Cav3.1 Calcium Channels and Electrophysiological Effects of T-type Calcium Channel Blockade in the Motor Thalamus of MPTP-treated Monkeys

Annaelle Devergnas, Erdong Chen, Yuxian Ma, Ikuma Hamada, Damien Pittard, Stefan Kammermeier, Ariana P Mullin, Victor Faundez, Craig W Lindsley, Carrie Jones, Yoland Smith, Thomas Wichmann

J Neurophysiol. 2016 Jan 1;115(1):470-85.

PMID: 26538609

1

Dorsal Root Ganglion Neurons Become Hyperexcitable and Increase Expression of Voltage-Gated T-type Calcium Channels (Cav3.2) in Paclitaxel-Induced Peripheral Neuropathy

Yan Li, Claudio Esteves Tatsui, Laurence D Rhines, Robert Y North, Daniel S Harrison, Ryan M Cassidy, Caj A Johansson, Alyssa K Kosturakis, Denaya D Edwards, Hongmei Zhang, Patrick M Dougherty

Pain. 2017 Mar;158(3):417-429.

PMID: 27902567

1

Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys

Adriana Galvan, Annaelle Devergnas, Damien Pittard, Gunasingh Masilamoni, Jocelyn Vuong, J Scott Daniels, Ryan D Morrison, Craig W Lindsley, Thomas Wichmann

ACS Chem Neurosci. 2016 Nov 16;7(11):1543-1551.

PMID: 27596273

1

Mibefradil, a T-type Ca 2+ channel blocker also blocks Orai channels by action at the extracellular surface

Pengyun Li, Hussein N Rubaiy, Gui-Lan Chen, Thomas Hallett, Nawel Zaibi, Bo Zeng, Rahul Saurabh, Shang-Zhong Xu

Br J Pharmacol. 2019 Oct;176(19):3845-3856.

PMID: 31271653

1

Scaffold Hopping Affords a Highly Selective

Xinmin Xie, John T. Brogan, Michael L. Schulte, Debbie Mi, Haibo Yu, Eric S. Dawson, Min Li, Owen McManus, Julie Engers, L. Michelle Lewis, Analisa Thompson, Carrie K. Jones, C. David Weaver, Craig W. Lindsley

PMID: 23762962

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