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ML252

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For Research Use Only | Not For Clinical Use
CATAP1392494642
CAS1392494-64-2
Molecular Weight308.42
Description≥98% (HPLC)
SolubilityDMSO: 25 mg/mL, clear
Assay≥98% (HPLC)
Color, light to dark purple
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery of a Series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches That Modulate Modes of K(v)7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant K(v)7.2 Channel Inhibitor

Yiu-Yin Cheung, Haibo Yu, Kaiping Xu, Beiyan Zou, Meng Wu, Owen B McManus, Min Li, Craig W Lindsley, Corey R Hopkins

J Med Chem. 2012 Aug 9;55(15):6975-9.

PMID: 22793372

1

Identification of a Novel, Small Molecule Inhibitor of KCNQ2 Channels

Haibo Yu, Kaiping Xu, Beiyan Zou, Meng Wu, Owen B. McManus, Julie Le Engers, Yiu-Yin Cheung, James M. Salovich, Corey R. Hopkins, Craig W. Lindsley, Min Li

PMID: 23658963

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