ML277

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For Research Use Only | Not For Clinical Use

CAT	IAR4244066
MDL Number	MFCD23704792
Molecular Weight	471.59
InChI Key	UKSXJENCMIVQMU-HXUWFJFHSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 5 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

Action Potential Shortening Rescues Atrial Calcium Alternans

Giedrius Kanaporis, Zane M Kalik, Lothar A Blatter

J Physiol. 2019 Feb;597(3):723-740.

PMID: 30412286

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a Novel, Potent and Selective K(v)7.1 (KCNQ1) Potassium Channel Activator

Margrith E Mattmann, Haibo Yu, Zhihong Lin, Kaiping Xu, Xiaofang Huang, Shunyou Long, Meng Wu, Owen B McManus, Darren W Engers, Uyen M Le, Min Li, Craig W Lindsley, Corey R Hopkins

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.

PMID: 22910039

ML277 Specifically Enhances the Fully Activated Open State of KCNQ1 by Modulating VSD-pore Coupling

Panpan Hou, Jingyi Shi, Kelli McFarland White, Yuan Gao, Jianmin Cui

Elife. 2019 Jul 22;8:e48576.

PMID: 31329101

Probing Binding Sites and Mechanisms of Action of an I(Ks) Activator by Computations and Experiments

Yu Xu, Yuhong Wang, Mei Zhang, Min Jiang, Avia Rosenhouse-Dantsker, Tsjerk Wassenaar, Gea-Ny Tseng

Biophys J. 2015 Jan 6;108(1):62-75.

PMID: 25564853

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