CAS 1443246-62-5 ML297 - Analytical Products / Alfa Chemistry

CAT	AP1443246625
CAS	1443246-62-5
Molecular Weight	328.32

Description	≥98% (HPLC)
Solubility	DMSO: 15 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

Activation of G-protein-gated Inwardly Rectifying Potassium (Kir3/GirK) Channels Rescues Hippocampal Functions in a Mouse Model of Early amyloid-β Pathology

Irene Sánchez-Rodríguez, Sara Temprano-Carazo, Alberto Nájera, Souhail Djebari, Javier Yajeya, Agnès Gruart, José M Delgado-García, Lydia Jiménez-Díaz, Juan D Navarro-López

Sci Rep. 2017 Nov 7;7(1):14658.

PMID: 29116174

1

Direct Activation of G-protein-gated Inward Rectifying K+ Channels Promotes Nonrapid Eye Movement Sleep

Bende Zou, William S Cao, Zhiwei Guan, Kui Xiao, Conrado Pascual, Julian Xie, Jingxi Zhang, James Xie, Frank Kayser, Craig W Lindsley, C David Weaver, Jidong Fang, Xinmin Simon Xie

Sleep. 2019 Mar 1;42(3):zsy244.

PMID: 30535004

1

Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel

Emily Days, Kristian Kaufmann, Ian Romaine, Colleen Niswender, Michelle Lewis, Thomas Utley, Yu Du, Gregory Sliwoski, Ryan Morrison, Eric S. Dawson, Julie L. Engers, Jerod Denton, J. Scott Daniels, Gary A. Sulikowski, etc.

PMID: 23762945

1

Mechanisms Underlying the Activation of G-protein-gated Inwardly Rectifying K+ (GIRK) Channels by the Novel Anxiolytic Drug, ML297

Nicole Wydeven, Ezequiel Marron Fernandez de Velasco, Yu Du, Michael A Benneyworth, Matthew C Hearing, Rachel A Fischer, Mark John Thomas, C David Weaver, Kevin Wickman

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10755-60.

PMID: 25002517

1

VU0810464, a non-urea G protein-gated inwardly rectifying K + (K ir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K ir 3 channels and reduces stress-induced hyperthermia in mice

Baovi N Vo, Kristopher K Abney, Allison Anderson, Ezequiel Marron Fernandez de Velasco, Michael A Benneyworth, John Scott Daniels, Ryan D Morrison, Corey R Hopkins, Charles David Weaver, Kevin Wickman

Br J Pharmacol. 2019 Jul;176(13):2238-2249.

PMID: 30924523

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