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MLS1547

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For Research Use Only | Not For Clinical Use
CATAP315698363
CAS315698-36-3
MDL NumberMFCD02330713
Molecular Weight354.83
InChI KeyOPEJNANYABTIGC-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery and Characterization of a G Protein-Biased Agonist That Inhibits β-arrestin Recruitment to the D2 Dopamine Receptor

R Benjamin Free, Lani S Chun, Amy E Moritz, Brittney N Miller, Trevor B Doyle, Jennie L Conroy, Adrian Padron, Julie A Meade, Jingbo Xiao, Xin Hu, Andrés E Dulcey, Yang Han, Lihua Duan, Steve Titus, Melanie Bryant-Genevier, etc.

Mol Pharmacol. 2014 Jul;86(1):96-105.

PMID: 24755247

1

Molecular Dynamics Simulation of Biased Agonists at the Dopamine D2 Receptor Suggests the Mechanism of Receptor Functional Selectivity

David Montgomery, Alexandra Campbell, Holli-Joi Sullivan, Chun Wu

J Biomol Struct Dyn. 2019 Aug;37(12):3206-3225.

PMID: 30124143

1

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D

Lani S Chun, Rakesh H Vekariya, R Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stephane A Laporte, Amy E Moritz, Jeffrey Aubé, Kevin J Frankowski, David R Sibley

Front Synaptic Neurosci. 2018 Feb 21;10:2.

PMID: 29515433

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