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NCT-501

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For Research Use Only | Not For Clinical Use
CATAP1802088501
CAS1802088-50-1
MDL NumberMFCD29472261
Molecular Weight416.52
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2

Lu Liu, Shurui Cai, Chunhua Han, Ananya Banerjee, Dayong Wu, Tiantian Cui, Guozhen Xie, Junran Zhang, Xiaoli Zhang, Eric McLaughlin, Ming Yin, Floor J Backes, Arnab Chakravarti, Yanfang Zheng, Qi-En Wang

Mol Cancer Ther. 2020 Jan;19(1):199-210.

PMID: 31534014

1

ALDH1A1 Maintains the Cancer Stem-Like Cells Properties of Esophageal Squamous Cell Carcinoma by Activating the AKT Signal Pathway and Interacting With β-catenin

Wei Wang, Shujin He, Renya Zhang, Jie Peng, Daolu Guo, Jinguo Zhang, Bo Xiang, Lei Li

Biomed Pharmacother. 2020 May;125:109940.

PMID: 32044720

1

Cancer Stem Cell Mediated Acquired Chemoresistance in Head and Neck Cancer Can Be Abrogated by Aldehyde Dehydrogenase 1 A1 Inhibition

Safeena Kulsum, Holalugunda Vittalamurthy Sudheendra, Ramanan Pandian, Doddathimmasandra Ramanjanappa Ravindra, Gangotri Siddappa, Nisheena R, Priyanka Chevour, Balaji Ramachandran, Milind Sagar, Aravindakshan Jayaprakash, etc.

Mol Carcinog. 2017 Feb;56(2):694-711.

PMID: 27380877

1

Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina

Rosemary E McDowell, Mary K McGahon, Josy Augustine, Mei Chen, J Graham McGeown, Tim M Curtis

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4762-71.

PMID: 27618414

1

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Shyh-Ming Yang, Adam Yasgar, Bettina Miller, Madhu Lal-Nag, Kyle Brimacombe, Xin Hu, Hongmao Sun, Amy Wang, Xin Xu, Kimloan Nguyen, Udo Oppermann, Marc Ferrer, Vasilis Vasiliou, Anton Simeonov, Ajit Jadhav, etc.

J Med Chem. 2015 Aug 13;58(15):5967-78.

PMID: 26207746

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