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NCT-503

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For Research Use Only | Not For Clinical Use
CATAP1916571908
CAS1916571-90-8
Molecular Weight408.48
InChI KeyPJNSZIQUFLWRLH-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery and Optimization of piperazine-1-thiourea-based Human Phosphoglycerate Dehydrogenase Inhibitors

Jason M Rohde, Kyle R Brimacombe, Li Liu, Michael E Pacold, Adam Yasgar, Dorian M Cheff, Tobie D Lee, Ganesha Rai, Bolormaa Baljinnyam, Zhuyin Li, Anton Simeonov, Matthew D Hall, Min Shen, David M Sabatini, etc.

Bioorg Med Chem. 2018 May 1;26(8):1727-1739.

PMID: 29555419

1

Genome-wide CRISPR/Cas9 Library Screening Identified PHGDH as a Critical Driver for Sorafenib Resistance in HCC

Lai Wei, Derek Lee, Cheuk-Ting Law, Misty Shuo Zhang, Jialing Shen, Don Wai-Ching Chin, Allen Zhang, Felice Ho-Ching Tsang, Ceci Lok-Sze Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong

Nat Commun. 2019 Oct 15;10(1):4681.

PMID: 31615983

1

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis

Robert B Hamanaka, Recep Nigdelioglu, Angelo Y Meliton, Yufeng Tian, Leah J Witt, Erin O'Leary, Kaitlyn A Sun, Parker S Woods, David Wu, Brandon Ansbro, Shawn Ard, Jason M Rohde, Nickolai O Dulin, Robert D Guzy, etc.

Am J Respir Cell Mol Biol. 2018 May;58(5):585-593.

PMID: 29019702

1

Overcoming Erlotinib Resistance in EGFR Mutation-Positive Lung Adenocarcinomas Through Repression of Phosphoglycerate Dehydrogenase

Jiang-Kai Dong, Hui-Min Lei, Qian Liang, Ya-Bin Tang, Ye Zhou, Yang Wang, Shengzhe Zhang, Wen-Bin Li, Yunguang Tong, Guanglei Zhuang, Liang Zhang, Hong-Zhuan Chen, Liang Zhu, Ying Shen

Theranostics. 2018 Feb 12;8(7):1808-1823.

PMID: 29556358

1

Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells

Emilia Białopiotrowicz, Monika Noyszewska-Kania, Neli Kachamakova-Trojanowska, Agnieszka Łoboda, Magdalena Cybulska, Aleksandra Grochowska, Michał Kopczyński, Michał Mikula, Monika Prochorec-Sobieszek, etc.

Cancers (Basel). 2020 Mar 3;12(3):580.

PMID: 32138178

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