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Necrostatin-5

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For Research Use Only | Not For Clinical Use
CATAP337349549
CAS337349-54-9
Structure
MDL NumberMFCD01448275
Molecular Weight383.49
InChI KeyVGONMECBFMCKBS-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: >10 mg/mL
Assay≥98% (HPLC)
Colorwhite to off-white
Formsolid
Size5MG, 25MG
Storage Conditions2-8°C
1

Identification of RIP1 Kinase as a Specific Cellular Target of Necrostatins

Alexei Degterev, Junichi Hitomi, Megan Germscheid, Irene L Ch'en, Olga Korkina, Xin Teng, Derek Abbott, Gregory D Cuny, Chengye Yuan, Gerhard Wagner, Stephen M Hedrick, Scott A Gerber, Alexey Lugovskoy, etc.

Nat Chem Biol. 2008 May;4(5):313-21.

PMID: 18408713

1

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis Following Pneumococcal Myocardial Invasion

Ryan P Gilley, Norberto González-Juarbe, Anukul T Shenoy, Luis F Reyes, Peter H Dube, Marcos I Restrepo, Carlos J Orihuela

Infect Immun. 2016 Apr 22;84(5):1457-69.

PMID: 26930705

1

Pore-Forming Toxins Induce Macrophage Necroptosis During Acute Bacterial Pneumonia

Norberto González-Juarbe, Ryan Paul Gilley, Cecilia Anahí Hinojosa, Kelley Margaret Bradley, Akinobu Kamei, Geli Gao, Peter Herman Dube, Molly Ann Bergman, Carlos Javier Orihuela

PLoS Pathog. 2015 Dec 11;11(12):e1005337.

PMID: 26659062

1

Structure-activity Relationship Analysis of a Novel Necroptosis Inhibitor, Necrostatin-5

Ke Wang, Jinfeng Li, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65.

PMID: 17270434

1

Study of Cardioprotective Effects of Necroptosis Inhibitors on Isolated Rat Heart Subjected to Global Ischemia-Reperfusion

Yu V Dmitriev, S M Minasian, E A Demchenko, M M Galagudza

Bull Exp Biol Med. 2013 Jun;155(2):245-8.

PMID: 24131001

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