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Nitisinone

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For Research Use Only | Not For Clinical Use
CATAP104206657
CAS104206-65-7
Structure
MDL NumberMFCD01752192
Molecular Weight329.23
InChI KeyOUBCNLGXQFSTLU-UHFFFAOYSA-N
Description≥95% (HPLC)
SolubilityDMSO: ≥5 mg/mL
Assay≥95% (HPLC)
Colorwhite to brown
Formpowder
Size10MG, 50MG
Storage Conditions−20°C
1

Efficacy of Low Dose Nitisinone in the Management of Alkaptonuria

Natacha Sloboda, Arnaud Wiedemann, Marc Merten, Amerh Alqahtani, Elise Jeannesson, Alain Blum, Sophie Henn-Ménétré, Jean-Louis Guéant, Emeline Renard, François Feillet

Mol Genet Metab. 2019 Jul;127(3):184-190.

PMID: 31235217

1

Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3

Ighovie F Onojafe, Lucyanne H Megan, Madeline G Melch, Joseph O Aderemi, Ramakrishna P Alur, Mones S Abu-Asab, Chi-Chao Chan, Isa M Bernardini, Jessica S Albert, Tiziana Cogliati, David R Adams, Brian P Brooks

Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):4945-4952.

PMID: 30347088

1

Nitisinone Arrests Ochronosis and Decreases Rate of Progression of Alkaptonuria: Evaluation of the Effect of Nitisinone in the United Kingdom National Alkaptonuria Centre

L R Ranganath, M Khedr, A M Milan, A S Davison, A T Hughes, J L Usher, S Taylor, N Loftus, A Daroszewska, E West, A Jones, M Briggs, M Fisher, M McCormick, S Judd, S Vinjamuri, R Griffin, E E Psarelli, etc.

Mol Genet Metab. 2018 Sep;125(1-2):127-134.

PMID: 30055994

1

Quantification of the Flux of Tyrosine Pathway Metabolites During Nitisinone Treatment of Alkaptonuria

A M Milan, A T Hughes, A S Davison, M Khedr, J Rovensky, E E Psarelli, T F Cox, N P Rhodes, J A Gallagher, L R Ranganath

Sci Rep. 2019 Jul 11;9(1):10024.

PMID: 31296884

1

Tyrosinemia Type I

Lisa Sniderman King, Cristine Trahms, C Ronald Scott, Margaret P Adam, Holly H Ardinger, Roberta A Pagon, Stephanie E Wallace, Lora JH Bean, Karen Stephens, Anne Amemiya

PMID: 20301688

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