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NMS-873

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For Research Use Only | Not For Clinical Use
CATAP1418013758
CAS1418013-75-8
MDL NumberMFCD28009371
Molecular Weight520.67
InChI KeyUJGTUKMAJVCBIS-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 25 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Adapted ATPase Domain Communication Overcomes the Cytotoxicity of p97 Inhibitors

Yang Wei, Julia I Toth, Gabrielle A Blanco, Andrey A Bobkov, Matthew D Petroski

J Biol Chem. 2018 Dec 28;293(52):20169-20180.

PMID: 30381397

1

Covalent and Allosteric Inhibitors of the ATPase VCP/p97 Induce Cancer Cell Death

Paola Magnaghi, Roberto D'Alessio, Barbara Valsasina, Nilla Avanzi, Simona Rizzi, Daniela Asa, Fabio Gasparri, Liviana Cozzi, Ulisse Cucchi, Christian Orrenius, Paolo Polucci, Dario Ballinari, Claudia Perrera, etc.

Nat Chem Biol. 2013 Sep;9(9):548-56.

PMID: 23892893

1

Essential Function of VCP/p97 in Infection Cycle of the Nucleopolyhedrovirus AcMNPV in Spodoptera Frugiperda Sf9 Cells

Yulia V Lyupina, Pavel A Erokhov, Oksana I Kravchuk, Alexander D Finoshin, Svetlana B Abaturova, Olga V Orlova, Svetlana N Beljelarskaya, Margarita V Kostyuchenko, Victor S Mikhailov

Virus Res. 2018 Jul 15;253:68-76.

PMID: 29890203

1

Identification of NMS-873, an Allosteric and Specific p97 Inhibitor, as a Broad Antiviral Against Both Influenza A and B Viruses

Jiantao Zhang, Yanmei Hu, Raymond Hau, Rami Musharrafieh, Chunlong Ma, Xu Zhou, Yin Chen, Jun Wang

Eur J Pharm Sci. 2019 May 15;133:86-94.

PMID: 30930289

1

p97 Composition Changes Caused by Allosteric Inhibition Are Suppressed by an On-Target Mechanism That Increases the Enzyme's ATPase Activity

Nam-Gu Her, Julia I Toth, Chen-Ting Ma, Yang Wei, Khatereh Motamedchaboki, Eduard Sergienko, Matthew D Petroski

Cell Chem Biol. 2016 Apr 21;23(4):517-28.

PMID: 27105284

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