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NN414

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For Research Use Only | Not For Clinical Use
CATAP279215439
CAS279215-43-9
Structure
MDL NumberMFCD18711369
Molecular Weight291.78
InChI KeyKYSFUHHFTIGRJN-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 15 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1-selective K(+) Channel Opener?

Xiaoning Fan, Yuyan Ding, Haiying Cheng, Dorte X Gram, Robert S Sherwin, Rory J McCrimmon

Diabetes. 2008 Dec;57(12):3327-34.

PMID: 18776135

1

Chronic exposure to K ATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons

Elizabeth Haythorne, D Lee Hamilton, John A Findlay, Craig Beall, Rory J McCrimmon, Michael L J Ashford

Neuropharmacology. 2016 Dec;111:212-222.

PMID: 27618741

1

Continuous Hypothalamic K(ATP) Activation Blunts Glucose Counter-Regulation in Vivo in Rats and Suppresses K(ATP) Conductance in Vitro

Craig Beall, Elizabeth Haythorne, Xiaoning Fan, Qingyou Du, Sofija Jovanovic, Robert S Sherwin, Michael L J Ashford, Rory J McCrimmon

Diabetologia. 2013 Sep;56(9):2088-92.

PMID: 23793715

1

Effects of cyclooxygenase-2 Inhibitor and Adenosine Triphosphate-Sensitive Potassium Channel Opener in Syngeneic Mouse Islet Transplantation

J-H Juang, C-H Kuo

Transplant Proc. 2010 Dec;42(10):4221-4.

PMID: 21168669

1

NN414, a SUR1/Kir6.2-selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Richard D Carr, Christian L Brand, Thora B Bodvarsdottir, John B Hansen, Jeppe Sturis

Diabetes. 2003 Oct;52(10):2513-8.

PMID: 14514634

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