NS6180

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For Research Use Only | Not For Clinical Use
CATAP353262041
CAS353262-04-1
Molecular Weight323.33
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C

1A High-Throughput Screening Campaign for Detection of ca(2+)-activated k(+) Channel Activators and Inhibitors Using a Fluorometric Imaging Plate Reader-Based tl(+)-influx Assay

Susanne Jørgensen, Tino Dyhring, David T Brown, Dorte Strøbæk, Palle Christophersen, Joachim Demnitz

Assay Drug Dev Technol. 2013 Apr;11(3):163-72.

PMID: 23198866

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1Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

Shyny Koshy, Danli Wu, Xueyou Hu, Rajeev B Tajhya, Redwan Huq, Fatima S Khan, Michael W Pennington, Heike Wulff, Patricia Yotnda, Christine Beeton

PLoS One. 2013 Oct 11;8(10):e76740.

PMID: 24146918

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1KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma

Brandon M Brown, Brandon Pressley, Heike Wulff

Curr Neuropharmacol. 2018;16(5):618-626.

PMID: 28676010

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1NS6180, a New K(Ca) 3.1 Channel Inhibitor Prevents T-cell Activation and Inflammation in a Rat Model of Inflammatory Bowel Disease

D Strøbæk, D T Brown, D P Jenkins, Y-J Chen, N Coleman, Y Ando, P Chiu, S Jørgensen, J Demnitz, H Wulff, P Christophersen

Br J Pharmacol. 2013 Jan;168(2):432-44.

PMID: 22891655

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1Structural Insights Into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore

Hai M Nguyen, Vikrant Singh, Brandon Pressly, David Paul Jenkins, Heike Wulff, Vladimir Yarov-Yarovoy

Mol Pharmacol. 2017 Apr;91(4):392-402.

PMID: 28126850

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