CAS 161058-83-9 NU2058 - Analytical Products / Alfa Chemistry

CAT	AP161058839
CAS	161058-83-9
MDL Number	MFCD05664734
Molecular Weight	247.30
InChI Key	MWGXGTJJAOZBNW-UHFFFAOYSA-N

Description	>98% (HPLC)
Solubility	DMSO: 22 mg/mL; H2O: soluble
Assay	>98% (HPLC)
Color	white
Size	5MG
Storage Conditions	2-8°C

1

N2-substituted O6-cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Ian R Hardcastle, Christine E Arris, Johanne Bentley, F Thomas Boyle, Yuzhu Chen, Nicola J Curtin, Jane A Endicott, Ashleigh E Gibson, Bernard T Golding, Roger J Griffin, Philip Jewsbury, Jerome Menyerol, etc.

J Med Chem. 2004 Jul 15;47(15):3710-22.

PMID: 15239650

1

Pre-clinical Evaluation of Cyclin-Dependent Kinase 2 and 1 Inhibition in Anti-Estrogen-Sensitive and Resistant Breast Cancer Cells

N Johnson, J Bentley, L-Z Wang, D R Newell, C N Robson, G I Shapiro, N J Curtin

Br J Cancer. 2010 Jan 19;102(2):342-50.

PMID: 20010939

1

The Development of a CDK2-docking Site Peptide That Inhibits p53 and Sensitizes Cells to Death

Michelle Ferguson, M Gloria Luciani, Lee Finlan, Elaine M Rankin, Sally Ibbotson, Alan Fersht, Tedd R Hupp

Cell Cycle. 2004 Jan;3(1):80-9.

PMID: 14657672

1

The Kinase Inhibitor O6-cyclohexylmethylguanine (NU2058) Potentiates the Cytotoxicity of Cisplatin by Mechanisms That Are Independent of Its Effect Upon CDK2

Luke R E Harrison, Christopher J Ottley, D Graham Pearson, Céline Roche, Stephen R Wedge, M Eileen Dolan, David R Newell, Michael J Tilby

Biochem Pharmacol. 2009 May 15;77(10):1586-92.

PMID: 19426695

1

Therapeutic Potential of CDK Inhibitor NU2058 in Androgen-Independent Prostate Cancer

A C Rigas, C N Robson, N J Curtin

Oncogene. 2007 Dec 6;26(55):7611-9.

PMID: 17599054

* Products or Services Interested: NU2058 (161058-83-9)
* Your question
* Name
* Email
Verification Code