CAS 220036-08-8 NU6027 - Analytical Products / Alfa Chemistry

CAT	AP220036088
CAS	220036-08-8
MDL Number	MFCD05664735
Molecular Weight	251.28
InChI Key	DGWXOLHKVGDQLN-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 15 mg/mL
Assay	≥98% (HPLC)
Color	lavender
MP	252.5-253.7 °C (lit.)
Size	5MG
Storage Conditions	2-8°C

1

4-Alkoxy-2,6-diaminopyrimidine Derivatives: Inhibitors of Cyclin Dependent Kinases 1 and 2

Veronique Mesguiche, Rachel J Parsons, Christine E Arris, Johanne Bentley, F Thomas Boyle, Nicola J Curtin, Thomas G Davies, Jane A Endicott, Ashleigh E Gibson, Bernard T Golding, Roger J Griffin, Philip Jewsbury, etc.

Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22.

PMID: 12482427

1

Contribution of Zinc-Dependent Delayed Calcium Influx via TRPC5 in Oxidative Neuronal Death and Its Prevention by Novel TRPC Antagonist

Sang Eun Park, Ji Hoon Song, Chansik Hong, Dong Eun Kim, Jee-Won Sul, Tae-Youn Kim, Bo-Ra Seo, Insuk So, Sang-Yeob Kim, Dong-Jun Bae, Mi-Ha Park, Hye Min Lim, In-Jeoung Baek, Antonio Riccio, Joo-Yong Lee, etc.

Mol Neurobiol. 2019 Apr;56(4):2822-2835.

PMID: 30062674

1

Identification and Evaluation of a Potent Novel ATR Inhibitor, NU6027, in Breast and Ovarian Cancer Cell Lines

A Peasland, L-Z Wang, E Rowling, S Kyle, T Chen, A Hopkins, W A Cliby, J Sarkaria, G Beale, R J Edmondson, N J Curtin

Br J Cancer. 2011 Jul 26;105(3):372-81.

PMID: 21730979

1

NU-6027 Inhibits Growth of Mycobacterium Tuberculosis by Targeting Protein Kinase D and Protein Kinase G

Saqib Kidwai, Rania Bouzeyen, Sohini Chakraborti, Neha Khare, Sumana Das, Tannu Priya Gosain, Assirbad Behura, Chhuttan Lal Meena, Rohan Dhiman, Makram Essafi, Avinash Bajaj, Deepak Kumar Saini, Narayanaswamy Srinivasan, etc.

Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00996-19.

PMID: 31285226

1

Synthesis and Biological Evaluation of N(2) -Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors

Daniela Cortese, Konstantin Chegaev, Stefano Guglielmo, Lan Z Wang, Bernard T Golding, Céline Cano, Roberta Fruttero

ChemMedChem. 2016 Aug 19;11(16):1705-8.

PMID: 27355194

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