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Nutlin-3a

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For Research Use Only | Not For Clinical Use
CATAP675576984
CAS675576-98-4
Structure
MDL NumberMFCD14636430
Molecular Weight581.49
InChI KeyBDUHCSBCVGXTJM-WUFINQPMSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Combination Treatment With Auranofin and nutlin-3a Induces Synergistic Cytotoxicity in Breast Cancer Cells

Dong-Jin Ye, Yeo-Jung Kwon, Hyoung-Seok Baek, Eunah Cho, Tae-Uk Kwon, Young-Jin Chun

J Toxicol Environ Health A. 2019;82(10):626-637.

PMID: 31258040

1

Nutlin-3a as a Novel Anticancer Agent for Adrenocortical Carcinoma With CTNNB1 Mutation

Wen Hui, Shenghua Liu, Jie Zheng, Zujun Fang, Qiang Ding, Chenchen Feng

Cancer Med. 2018 Apr;7(4):1440-1449.

PMID: 29532999

1

Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I Pishas, Susan J Neuhaus, Mark T Clayer, Andreas W Schreiber, David M Lawrence, Michelle Perugini, Robert J Whitfield, Gelareh Farshid, Jim Manavis, Steve Chryssidis, Bronwen J Mayo, Rebecca C Haycox, etc.

Cancer Res. 2014 Feb 1;74(3):921-31.

PMID: 24336067

1

Nutlin-3a Nanodisks Induce p53 Stabilization and Apoptosis in a Subset of Cultured Glioblastoma Cells

A Krishnamoorthy, A Witkowski, R O Ryan

J Nanomed Nanotechnol. 2017 Aug;8(4):454.

PMID: 28966869

1

Nutlin-3a Selects for Cells Harbouring TP53 Mutations

Jill E Kucab, Monica Hollstein, Volker M Arlt, David H Phillips

Int J Cancer. 2017 Feb 15;140(4):877-887.

PMID: 27813088

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