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NVP-231

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For Research Use Only | Not For Clinical Use
CATAP362003836
CAS362003-83-6
Structure
MDL NumberMFCD01988824
Molecular Weight431.55
InChI KeyMVSSJPGNLQPWSW-CIRRPZLZSA-N
Description≥98% (HPLC)
SolubilityDMSO: >10 mg/mL
Assay≥98% (HPLC)
Colorwhite to off-white
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Ceramide Kinase Contributes to Proliferation but Not to Prostaglandin E2 Formation in Renal Mesangial Cells and Fibroblasts

Oleksandr Pastukhov, Stephanie Schwalm, Isolde Römer, Uwe Zangemeister-Wittke, Josef Pfeilschifter, Andrea Huwiler

Cell Physiol Biochem. 2014;34(1):119-33.

PMID: 24977486

1

Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt

Stephanie Schwalm, Martin Erhardt, Isolde Römer, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler

Int J Mol Sci. 2020 Feb 19;21(4):1396.

PMID: 32092937

1

Ceramide-1-phosphate Protection of Cochlear Hair Cells Against Cisplatin Ototoxicity

Quang Le, Keiji Tabuchi, Akira Hara

Toxicol Rep. 2016 Apr 14;3:450-457.

PMID: 28959567

1

Targeting Ceramide Metabolism With a Potent and Specific Ceramide Kinase Inhibitor

Christine Graf, Martin Klumpp, Michael Habig, Philipp Rovina, Andreas Billich, Thomas Baumruker, Berndt Oberhauser, Frédéric Bornancin

Mol Pharmacol. 2008 Oct;74(4):925-32.

PMID: 18612076

1

The Ceramide Kinase Inhibitor NVP-231 Inhibits Breast and Lung Cancer Cell Proliferation by Inducing M Phase Arrest and Subsequent Cell Death

Oleksandr Pastukhov, Stephanie Schwalm, Uwe Zangemeister-Wittke, Doriano Fabbro, Frederic Bornancin, Lukasz Japtok, Burkhard Kleuser, Josef Pfeilschifter, Andrea Huwiler

Br J Pharmacol. 2014 Dec;171(24):5829-44.

PMID: 25134723

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