0

OTX015

INQUIRY Add to cart
For Research Use Only | Not For Clinical Use
CATAP202590985
CAS202590-98-5
MDL NumberMFCD26960949
Molecular Weight491.99
InChI KeyGNMUEVRJHCWKTO-FQEVSTJZSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

BET Inhibitor OTX015 Targets BRD2 and BRD4 and Decreases c-MYC in Acute Leukemia Cells

Marie-Magdelaine Coudé, Thorsten Braun, Jeannig Berrou, Mélanie Dupont, Sibyl Bertrand, Aline Masse, Emmanuel Raffoux, Raphaël Itzykson, Marc Delord, Maria E Riveiro, Patrice Herait, André Baruchel, Hervé Dombret, etc.

Oncotarget. 2015 Jul 10;6(19):17698-712.

PMID: 25989842

1

Novel BET Protein Proteolysis-Targeting Chimera Exerts Superior Lethal Activity Than Bromodomain Inhibitor (BETi) Against Post-Myeloproliferative Neoplasm Secondary (S) AML Cells

D T Saenz, W Fiskus, Y Qian, T Manshouri, K Rajapakshe, K Raina, K G Coleman, A P Crew, A Shen, C P Mill, B Sun, P Qiu, T M Kadia, N Pemmaraju, C DiNardo, M-S Kim, A J Nowak, C Coarfa, C M Crews, S Verstovsek, etc.

Leukemia. 2017 Sep;31(9):1951-1961.

PMID: 28042144

1

OTX015 (MK-8628), a Novel BET Inhibitor, Displays in Vitro and in Vivo Antitumor Effects Alone and in Combination With Conventional Therapies in Glioblastoma Models

Caroline Berenguer-Daizé, Lucile Astorgues-Xerri, Elodie Odore, Mylène Cayol, Esteban Cvitkovic, Kay Noel, Mohamed Bekradda, Sarah MacKenzie, Keyvan Rezai, François Lokiec, Maria E Riveiro, L'Houcine Ouafik

Int J Cancer. 2016 Nov 1;139(9):2047-55.

PMID: 27388964

1

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition

Anton Henssen, Kristina Althoff, Andrea Odersky, Anneleen Beckers, Richard Koche, Frank Speleman, Simon Schäfers, Emma Bell, Maike Nortmeyer, Frank Westermann, Katleen De Preter, Alexandra Florin, Lukas Heukamp, etc.

Clin Cancer Res. 2016 May 15;22(10):2470-81.

PMID: 26631615

1

The Bromodomain and Extra-Terminal Protein Inhibitor OTX015 Suppresses T Helper Cell Proliferation and Differentiation

Xiao Hu, Lauren P Schewitz-Bowers, Philippa J P Lait, David A Copland, Madeleine L Stimpson, Jing Jing Li, Yizhi Liu, Andrew D Dick, Richard W J Lee, Lai Wei

Curr Mol Med. 2018;18(9):594-601.

PMID: 30683020

  • Verification code
Contact Us

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.
Online Inquiry

Online Inquiry

For any inquiry, question or recommendation, please call: or fill out the following form.

  • Verification code

Head Office

  • Tel:
  • Email:

Follow us on

qrcode