p97 ATPase Activity Inhibitor, DBeQ - Analytical Products / Alfa Chemistry

CAT	IAR42410914
Molecular Weight	340.42

Description	The p97 ATPase Activity Inhibitor, DBeQ controls the biological activity of p97 ATPase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Solubility	ethanol: 2.5 mg/mL; DMSO: 50 mg/mL
Assay	≥95% (HPLC)
Color	white
Form	solid; protect from light
Size	10MG
Storage Conditions	-20C

1

Development of p97 AAA ATPase Inhibitors

Tsui-Fen Chou, Raymond J Deshaies

Autophagy. 2011 Sep;7(9):1091-2.

PMID: 21606684

1

Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency Against the p97-p47 Complex

Chen-Jie Fang, Lin Gui, Xiaoyi Zhang, Derek R Moen, Kelin Li, Kevin J Frankowski, Henry J Lin, Frank J Schoenen, Tsui-Fen Chou

ChemMedChem. 2015 Jan;10(1):52-6.

PMID: 25377500

1

Novel p97/VCP Inhibitor Induces Endoplasmic Reticulum Stress and Apoptosis in Both Bortezomib-Sensitive and -Resistant Multiple Myeloma Cells

Nao Nishimura, Mohamed O Radwan, Masayuki Amano, Shinya Endo, Eri Fujii, Hironori Hayashi, Shikiko Ueno, Niina Ueno, Hiro Tatetsu, Hiroyuki Hata, Yoshinari Okamoto, Masami Otsuka, Hiroaki Mitsuya, Masao Matsuoka, etc.

Cancer Sci. 2019 Oct;110(10):3275-3287.

PMID: 31368616

1

Reversible Inhibitor of p97, DBeQ, Impairs Both Ubiquitin-Dependent and Autophagic Protein Clearance Pathways

Tsui-Fen Chou, Steve J Brown, Dmitriy Minond, Brian E Nordin, Kelin Li, Amanda C Jones, Peter Chase, Patrick R Porubsky, Brian M Stoltz, Frank J Schoenen, Matthew P Patricelli, Peter Hodder, Hugh Rosen, etc.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9.

PMID: 21383145

1

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction Between D1 and D2 ATPase Domains

Tsui-Fen Chou, Stacie L Bulfer, Conrad C Weihl, Kelin Li, Lev G Lis, Michael A Walters, Frank J Schoenen, Henry J Lin, Raymond J Deshaies, Michelle R Arkin

J Mol Biol. 2014 Jul 29;426(15):2886-99.

PMID: 24878061

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