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PA-6

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For Research Use Only | Not For Clinical Use
CATAP500715037
CAS500715-03-7
Molecular Weight492.61
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Adjuvant Treatment for Pancreatic Cancer

Ulla Klaiber, Thilo Hackert, John P Neoptolemos

Transl Gastroenterol Hepatol. 2019 Apr 29;4:27.

PMID: 31143848

1

Electrophysiologic Effects of the IK1 Inhibitor PA-6 Are Modulated by Extracellular Potassium in Isolated Guinea Pig Hearts

Gregory S Hoeker, Mark A Skarsfeldt, Thomas Jespersen, Steven Poelzing

Physiol Rep. 2017 Jan;5(1):e13120.

PMID: 28087819

1

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function K IR 2.1 channels, but increases channel protein expression

Yuan Ji, Marlieke G Veldhuis, Jantien Zandvoort, Fee L Romunde, Marien J C Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger, Marcel A G van der Heyden

J Biomed Sci. 2017 Jul 15;24(1):44.

PMID: 28711067

1

Pharmacological Inhibition of IK1 by PA-6 in Isolated Rat Hearts Affects Ventricular Repolarization and Refractoriness

Mark A Skarsfeldt, Helena Carstensen, Lasse Skibsbye, Chuyi Tang, Rikke Buhl, Bo H Bentzen, Thomas Jespersen

Physiol Rep. 2016 Apr;4(8):e12734.

PMID: 27117805

1

The Inward Rectifier Current Inhibitor PA-6 Terminates Atrial Fibrillation and Does Not Cause Ventricular Arrhythmias in Goat and Dog Models

Yuan Ji, Rosanne Varkevisser, Dragan Opacic, Alexandre Bossu, Marion Kuiper, Jet D M Beekman, Sihyung Yang, Azinwi Phina Khan, Dobromir Dobrev, Niels Voigt, Michael Zhuo Wang, Sander Verheule, Marc A Vos, etc.

Br J Pharmacol. 2017 Aug;174(15):2576-2590.

PMID: 28542844

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