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Paxilline

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For Research Use Only | Not For Clinical Use
CATAP57186251
CAS57186-25-1
Structure
MDL NumberMFCD00083464
Molecular Weight435.56
InChI KeyACNHBCIZLNNLRS-UBGQALKQSA-N
Descriptionpowder, ≥98% (HPLC)
Assay≥98% (HPLC)
Colorfaintly yellow
Formpowder
Size5MG, 10MG
Storage Conditions2-8°C
1

BK Channel Blocker Paxilline Attenuates Thalidomide-Caused Synaptic and Cognitive Dysfunctions in Mice

Tae-Yong Choi, Seung-Hyun Lee, Soo-Jeong Kim, Youhwa Jo, Chul-Seung Park, Se-Young Choi

Sci Rep. 2018 Dec 5;8(1):17653.

PMID: 30518785

1

Glycine311, a Determinant of Paxilline Block in BK Channels: A Novel Bend in the BK S6 Helix

Yu Zhou, Qiong-Yao Tang, Xiao-Ming Xia, Christopher J Lingle

J Gen Physiol. 2010 May;135(5):481-94.

PMID: 20421373

1

Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants

Julia I Bauer, Madeleine Gross, Benedikt Cramer, Hans-Ulrich Humpf, Gerd Hamscher, Ewald Usleber

J Agric Food Chem. 2018 Jan 10;66(1):315-322.

PMID: 29237259

1

Large-conductance Calcium-Activated Potassium Channels Mediate Lipopolysaccharide-Induced Activation of Murine Microglia

Xiaoying Yang, Guiqin Wang, Ting Cao, Li Zhang, Yunzhi Ma, Shuhui Jiang, Xinchen Teng, Xiaohui Sun

J Biol Chem. 2019 Aug 30;294(35):12921-12932.

PMID: 31296663

1

Paxilline Inhibits BK Channels by an Almost Exclusively Closed-Channel Block Mechanism

Yu Zhou, Christopher J Lingle

J Gen Physiol. 2014 Nov;144(5):415-40.

PMID: 25348413

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