CAS 290814-68-5 PBOX-6 - Analytical Products / Alfa Chemistry

CAT	AP290814685
CAS	290814-68-5
Molecular Weight	396.44

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Activation of the c-Jun N-terminal Kinase (JNK) Signaling Pathway Is Essential During PBOX-6-induced Apoptosis in Chronic Myelogenous Leukemia (CML) Cells

Margaret M Mc Gee, Giuseppe Campiani, Anna Ramunno, Vito Nacci, Mark Lawler, D Clive Williams, Daniela M Zisterer

J Biol Chem. 2002 May 24;277(21):18383-9.

PMID: 11856743

1

Selective Induction of Apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH2-terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-XL

Margaret M Mc Gee, Lisa M Greene, Susan Ledwidge, Giuseppe Campiani, Vito Nacci, Mark Lawler, D Clive Williams, Daniela M Zisterer

J Pharmacol Exp Ther. 2004 Sep;310(3):1084-95.

PMID: 15143129

1

The Microtubule-Targeting Agents, PBOX-6 [Pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and Paclitaxel, Induce Nucleocytoplasmic Redistribution of the Peptidyl-Prolyl Isomerases, Cyclophilin A and pin1, in Malignant Hematopoietic Cells

Fiona T Bane, John H Bannon, Stephen R Pennington, Giuseppe Campiani, D Clive Williams, Daniela M Zisterer, Margaret M Mc Gee

J Pharmacol Exp Ther. 2009 Apr;329(1):38-47.

PMID: 19131583

1

The Novel pyrrolo-1,5-benzoxazepine, PBOX-6, Synergistically Enhances the Apoptotic Effects of Carboplatin in Drug Sensitive and Multidrug Resistant Neuroblastoma Cells

Jennifer C Lennon, Sandra A Bright, Eilis Carroll, Stefania Butini, Giuseppe Campiani, Anne O'Meara, D Clive Williams, Daniela M Zisterer

Biochem Pharmacol. 2014 Feb 15;87(4):611-24.

PMID: 24406249

1

The pyrrolo-1,5-benzoxazepine, PBOX-6, Inhibits the Growth of Breast Cancer Cells in Vitro Independent of Estrogen Receptor Status and Inhibits Breast Tumour Growth in Vivo

Lisa M Greene, Marina Fleeton, Jude Mulligan, Chikkanna Gowda, Brian J Sheahan, Gregory J Atkins, Giuseppe Campiani, Vito Nacci, Mark Lawler, D Clive Williams, Daniela M Zisterer

Oncol Rep. 2005 Nov;14(5):1357-63.

PMID: 16211309

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