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PD 0325901

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For Research Use Only | Not For Clinical Use
CATAP391210109-B
CAS391210-10-9
Structure
MDL NumberMFCD08435926
Molecular Weight482.19
InChI KeySUDAHWBOROXANE-SECBINFHSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to off-white
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) Plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer

Zev A Wainberg, Maria Alsina, Heloisa P Soares, Irene Braña, Carolyn D Britten, Gianluca Del Conte, Patrick Ezeh, Brett Houk, Kenneth A Kern, Stephen Leong, Nuzhat Pathan, Kristen J Pierce, Lillian L Siu, etc.

Target Oncol. 2017 Dec;12(6):775-785.

PMID: 29067643

1

MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer

Yansong Bian, Jiawei Han, Vishnu Kannabiran, Suresh Mohan, Hui Cheng, Jay Friedman, Luo Zhang, Carter VanWaes, Zhong Chen

Int J Biol Sci. 2015 Feb 23;11(4):411-22.

PMID: 25798061

1

MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma

Suresh Mohan, Robert Vander Broek, Sujay Shah, Danielle F Eytan, Matthew L Pierce, Sophie G Carlson, Jamie F Coupar, Jialing Zhang, Hui Cheng, Zhong Chen, Carter Van Waes

Clin Cancer Res. 2015 Sep 1;21(17):3946-56.

PMID: 25977343

1

Pilot Study of PD-0325901 in Previously Treated Patients With Advanced Melanoma, Breast Cancer, and Colon Cancer

Peter D Boasberg, Charles H Redfern, Gregory A Daniels, David Bodkin, Chris R Garrett, Alejandro D Ricart

Cancer Chemother Pharmacol. 2011 Aug;68(2):547-52.

PMID: 21516509

1

Preclinical Assessments of the MEK Inhibitor PD-0325901 in a Mouse Model of Neurofibromatosis Type 1

Edwin Jousma, Tilat A Rizvi, Jianqiang Wu, David Janhofer, Eva Dombi, Richard S Dunn, Mi-Ok Kim, Andrea R Masters, David R Jones, Timothy P Cripe, Nancy Ratner

Pediatr Blood Cancer. 2015 Oct;62(10):1709-16.

PMID: 25907661

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