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PD184352

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For Research Use Only | Not For Clinical Use
CATAP212631793
CAS212631-79-3
Structure
MDL NumberMFCD02683961
Molecular Weight478.66
InChI KeyGFMMXOIFOQCCGU-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: ≥30 mg/mL
Assay≥98% (HPLC)
Colorwhite to tan
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Cell-cycle Arrest by PD184352 Requires Inhibition of Extracellular Signal-Regulated Kinases (ERK) 1/2 but Not ERK5/BMK1

Matthew S Squires, Paula M Nixon, Simon J Cook

Biochem J. 2002 Sep 1;366(Pt 2):673-80.

PMID: 12069688

1

MEK-inhibitor PD184352 Enhances the Radiosensitizing Effect of the Hsp90 Inhibitor NVP-AUY922: The Role of Cell Type and Drug-Irradiation Schedule

Felix Grabenbauer, Astrid Katzer, Dmitri Sisario, Simon Memmel, Michael Flentje, Vladimir L Sukhorukov, Cholpon S Djuzenova

Oncotarget. 2018 Dec 21;9(100):37379-37392.

PMID: 30647839

1

NMDA Receptor-Dependent Signalling Pathways Regulate Arginine Vasopressin Expression in the Paraventricular Nucleus of the Rat

David Lake, Sonia A L Corrêa, Jürgen Müller

Brain Res. 2019 Nov 1;1722:146357.

PMID: 31369731

1

Targeting the ERK Signaling Pathway as a Potential Treatment for Insulin Resistance and Type 2 Diabetes

Kei-Ichi Ozaki, Midori Awazu, Mayuko Tamiya, Yuka Iwasaki, Aya Harada, Satomi Kugisaki, Susumu Tanimura, Michiaki Kohno

Am J Physiol Endocrinol Metab. 2016 Apr 15;310(8):E643-E651.

PMID: 26860984

1

The Mitogen-Activated Protein kinase/extracellular Signal-Regulated Kinase Kinase Inhibitor PD184352 (CI-1040) Selectively Induces Apoptosis in Malignant Schwannoma Cell Lines

Raymond R Mattingly, Janice M Kraniak, Joshua T Dilworth, Patricia Mathieu, Beverly Bealmear, James E Nowak, Joyce A Benjamins, Michael A Tainsky, John J Reiners Jr

J Pharmacol Exp Ther. 2006 Jan;316(1):456-65.

PMID: 16239399

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