PDE10A Active from rat - Analytical Products / Alfa Chemistry

CAT

IAR4245710

Description	recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)
Assay	≥80% (SDS-PAGE)
Form	aqueous solution
Size	5μG
Storage Conditions	−70°C

1

Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor

Yoichi Kadoh, Haruko Miyoshi, Takehiko Matsumura, Yoshihito Tanaka, Mitsuya Hongu, Mayumi Kimura, Kei Takedomi, Kenji Omori, Jun Kotera, Takashi Sasaki, Tamaki Kobayashi, Hiroyuki Taniguchi, Yumi Watanabe, etc.

Chem Pharm Bull (Tokyo). 2018;66(3):243-250.

PMID: 29491258

1

Immunohistochemical Localization of PDE10A in the Rat Brain

Thomas F Seeger, Brenda Bartlett, Timothy M Coskran, Jeffrey S Culp, Larry C James, David L Krull, Jerry Lanfear, Anne M Ryan, Christopher J Schmidt, Christine A Strick, Alison H Varghese, Robert D Williams, etc.

Brain Res. 2003 Sep 26;985(2):113-26.

PMID: 12967715

1

Metabolic Regulation of Glycolysis and AMP Activated Protein Kinase Pathways During Black Raspberry-Mediated Oral Cancer Chemoprevention

Thomas J Knobloch, Nathan M Ryan, Lei Bruschweiler-Li, Cheng Wang, Matthew C Bernier, Arpad Somogyi, Pearlly S Yan, Jessica L Cooperstone, Xiaokui Mo, Rafael P Brüschweiler, Christopher M Weghorst, Steve Oghumu

Metabolites. 2019 Jul 11;9(7):140.

PMID: 31336728

1

PDE10A and PDE10A-dependent cAMP Catabolism Are Dysregulated Oppositely in Striatum and Nucleus Accumbens After Lesion of Midbrain Dopamine Neurons in Rat: A Key Step in Parkinsonism Physiopathology

M Giorgi, G Melchiorri, V Nuccetelli, V D'Angelo, A Martorana, R Sorge, V Castelli, G Bernardi, G Sancesario

Neurobiol Dis. 2011 Jul;43(1):293-303.

PMID: 21515371

1

Preclinical Evaluation of [(18)F]JNJ42259152 as a PET Tracer for PDE10A

S Celen, M Koole, M Ooms, M De Angelis, I Sannen, J Cornelis, J Alcazar, M Schmidt, A Verbruggen, X Langlois, K Van Laere, J I Andrés, G Bormans

Neuroimage. 2013 Nov 15;82:13-22.

PMID: 23664955

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