0

PF-01247324

INQUIRY Add to cart
For Research Use Only | Not For Clinical Use
CATAP875051722
CAS875051-72-2
Molecular Weight330.60
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

A Novel Selective and Orally Bioavailable Nav 1.8 Channel Blocker, PF-01247324, Attenuates Nociception and Sensory Neuron Excitability

Claire Elizabeth Payne, Adam R Brown, Jonathon W Theile, Alexandre J C Loucif, Aristos J Alexandrou, Mathew D Fuller, John H Mahoney, Brett M Antonio, Aaron C Gerlach, David M Printzenhoff, Rebecca L Prime, etc.

Br J Pharmacol. 2015 May;172(10):2654-70.

PMID: 25625641

1

Different role of TTX-sensitive voltage-gated sodium channel (Na V 1) subtypes in action potential initiation and conduction in vagal airway nociceptors

M Kollarik, H Sun, R A Herbstsomer, F Ru, M Kocmalova, S N Meeker, B J Undem

J Physiol. 2018 Apr 15;596(8):1419-1432.

PMID: 29435993

1

Differential Regulation of Sodium Channels as a Novel Proarrhythmic Mechanism in the Human Failing Heart

Nataliya Dybkova, Shakil Ahmad, Steffen Pabel, Petros Tirilomis, Nico Hartmann, Thomas H Fischer, Philipp Bengel, Theodoros Tirilomis, Senka Ljubojevic, André Renner, Jan Gummert, David Ellenberger, Stefan Wagner, etc.

Cardiovasc Res. 2018 Nov 1;114(13):1728-1737.

PMID: 29931291

1

Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

Shannon D Shields, Richard P Butt, Sulayman D Dib-Hajj, Stephen G Waxman

PLoS One. 2015 Mar 6;10(3):e0119067.

PMID: 25747279

1

The functional consequences of sodium channel Na V 1.8 in human left ventricular hypertrophy

Shakil Ahmad, Petros Tirilomis, Steffen Pabel, Nataliya Dybkova, Nico Hartmann, Cristina E Molina, Theodoros Tirilomis, Ingo Kutschka, Norbert Frey, Lars S Maier, Gerd Hasenfuss, Katrin Streckfuss-Bömeke, etc.

ESC Heart Fail. 2019 Feb;6(1):154-163.

PMID: 30378291

  • Verification code
Contact Us

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.
Online Inquiry

Online Inquiry

For any inquiry, question or recommendation, please call: or fill out the following form.

  • Verification code

Head Office

  • Tel:
  • Email:

Follow us on

qrcode