CAS 1082744-20-4 PF-04447943 - Analytical Products / Alfa Chemistry

CAT	AP1082744204
CAS	1082744-20-4
MDL Number	MFCD22665724
Molecular Weight	395.46

Description	≥98% (HPLC)
Solubility	DMSO: 2 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	room temp

1

A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer's Disease

Elias M Schwam, Timothy Nicholas, Robert Chew, Clare B Billing, Wendy Davidson, Darlene Ambrose, Larry D Altstiel

Curr Alzheimer Res. 2014;11(5):413-21.

PMID: 24801218

1

Cyclic Nucleotide Signalling Compartmentation by PDEs in Cultured Vascular Smooth Muscle Cells

Liang Zhang, Kaouter Bouadjel, Boris Manoury, Grégoire Vandecasteele, Rodolphe Fischmeister, Véronique Leblais

Br J Pharmacol. 2019 Jun;176(11):1780-1792.

PMID: 30825186

1

PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study

Robert J Charnigo, David Beidler, Denis Rybin, Debra D Pittman, Beesan Tan, Jo Howard, Alan D Michelson, Andrew L Frelinger , III, Nicholas Clarke

Clin Transl Sci. 2019 Mar;12(2):180-188.

PMID: 30597771

1

Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer's Disease: A Translational Overview

P R A Heckman, C Wouters, J Prickaerts

Curr Pharm Des. 2015;21(3):317-31.

PMID: 25159073

1

The Selective Phosphodiesterase 9 (PDE9) Inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) Enhances Synaptic Plasticity and Cognitive Function in Rodents

P H Hutson, E N Finger, B C Magliaro, S M Smith, A Converso, P E Sanderson, D Mullins, L A Hyde, B K Eschle, Z Turnbull, H Sloan, M Guzzi, X Zhang, A Wang, D Rindgen, R Mazzola, J A Vivian, D Eddins, J M Uslaner, etc.

Neuropharmacology. 2011 Sep;61(4):665-76.

PMID: 21619887

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