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PF-04457845

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For Research Use Only | Not For Clinical Use
CATAP1312473634
CAS1312473-63-4
Structure
MDL NumberMFCD22683813
Molecular Weight412.43
InChI KeyBATCTBJIJJEPHM-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Storage Conditionsroom temp
1

Different Routes to Inhibit Fatty Acid Amide Hydrolase: Do All Roads Lead to the Same Place?

Giacomo Giacovazzo, Tiziana Bisogno, Fabiana Piscitelli, Roberta Verde, Sergio Oddi, Mauro Maccarrone, Roberto Coccurello

Int J Mol Sci. 2019 Sep 11;20(18):4503.

PMID: 31514437

1

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

Douglas S Johnson, Cory Stiff, Scott E Lazerwith, Suzanne R Kesten, Lorraine K Fay, Mark Morris, David Beidler, Marya B Liimatta, Sarah E Smith, David T Dudley, Nalini Sadagopan, Shobha N Bhattachar, Stephen J Kesten, etc.

ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.

PMID: 21666860

1

Efficacy and Safety of a Fatty Acid Amide Hydrolase Inhibitor (PF-04457845) in the Treatment of Cannabis Withdrawal and Dependence in Men: A Double-Blind, Placebo-Controlled, Parallel Group, Phase 2a Single-Site Randomised Controlled Trial

Deepak Cyril D'Souza, Jose Cortes-Briones, Gina Creatura, Grai Bluez, Halle Thurnauer, Emma Deaso, Kim Bielen, Toral Surti, Rajiv Radhakrishnan, Aarti Gupta, Swapnil Gupta, John Cahill, Mohamed A Sherif, etc.

Lancet Psychiatry. 2019 Jan;6(1):35-45.

PMID: 30528676

1

Synthesis and Preclinical Evaluation of [11C-carbonyl]PF-04457845 for Neuroimaging of Fatty Acid Amide Hydrolase

Justin W Hicks, Jun Parkes, Oleg Sadovski, Junchao Tong, Sylvain Houle, Neil Vasdev, Alan A Wilson

Nucl Med Biol. 2013 Aug;40(6):740-6.

PMID: 23731552

1

The Cannabinoid System and Pain

Stephen G Woodhams, Victoria Chapman, David P Finn, Andrea G Hohmann, Volker Neugebauer

Neuropharmacology. 2017 Sep 15;124:105-120.

PMID: 28625720

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