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PF-04620110

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For Research Use Only | Not For Clinical Use
CATAP1109276892
CAS1109276-89-2
Molecular Weight396.44
InChI KeyGEVVQZHMFVFGLN-HDJSIYSDSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL (clear solution)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Defining the Key Pharmacophore Elements of PF-04620110: Discovery of a Potent, Orally-Active, Neutral DGAT-1 Inhibitor

Robert L Dow, Melissa P Andrews, Jian-Cheng Li, E Michael Gibbs, Angel Guzman-Perez, Jennifer L Laperle, Qifang Li, Dawn Mather, Michael J Munchhof, Mark Niosi, Leena Patel, Christian Perreault, Susan Tapley, etc.

Bioorg Med Chem. 2013 Sep 1;21(17):5081-97.

PMID: 23871442

1

Determination of PF-04620110, a Novel Inhibitor of Diacylglycerol acyltransferase-1, in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry and Its Application in Pharmacokinetic Studies

Kyeong-Ryoon Lee, Sung Heum Choi, Jin-Sook Song, Hyewon Seo, Yoon-Jee Chae, Hwang Eui Cho, Jin Hee Ahn, Sung-Hoon Ahn, Myung Ae Bae

Biomed Chromatogr. 2013 Jul;27(7):846-52.

PMID: 23420715

1

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

Robert L Dow, Jian-Cheng Li, Michael P Pence, E Michael Gibbs, Jennifer L LaPerle, John Litchfield, David W Piotrowski, Michael J Munchhof, Tara B Manion, William J Zavadoski, Gregory S Walker, R Kirk McPherson, etc.

ACS Med Chem Lett. 2011 Mar 18;2(5):407-12.

PMID: 24900321

1

PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages

Seung Il Jo, Jung Hwan Bae, Seong Jin Kim, Jong Min Lee, Ji Hun Jeong, Jong Seok Moon

Diabetes Metab J. 2019 Oct;43(5):683-699.

PMID: 31694081

1

Pharmacological Inhibition of Diacylglycerol acyltransferase-1 and Insights Into Postprandial Gut Peptide Secretion

Benjamin S Maciejewski, Tara B Manion, Claire M Steppan

World J Gastrointest Pathophysiol. 2017 Nov 15;8(4):161-175.

PMID: 29184702

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