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PF-04691502

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For Research Use Only | Not For Clinical Use
CATAP1013101364
CAS1013101-36-4
Molecular Weight425.48
InChI KeyXDLYKKIQACFMJG-WKILWMFISA-N
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Color, white to yellow to light brown
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
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PF-04691502 Triggers Cell Cycle Arrest, Apoptosis and Inhibits the Angiogenesis in Hepatocellular Carcinoma Cells

Feng-Ze Wang, Peng-Jiao, Na-Na Yang, Chuang-Yuan, Ya-Li Zhao, Qiang-Qiang Liu, Hong-Rong Fei, Ji-Guo Zhang

Toxicol Lett. 2013 Jul 4;220(2):150-6.

PMID: 23639247

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PF-04691502, a Dual PI3K/mTOR Inhibitor Has Potent Pre-Clinical Activity by Inducing Apoptosis and G1 Cell Cycle Arrest in Aggressive B-cell non-Hodgkin Lymphomas

Deyu Chen, Chaoming Mao, Yuepeng Zhou, Yuting Su, Shenzha Liu, Wen-Qing Qi

Int J Oncol. 2016 Jan;48(1):253-60.

PMID: 26549638

1

PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases With Antitumor Activity

Jing Yuan, Pramod P Mehta, Min-Jean Yin, Shaoxian Sun, Aihua Zou, Jeffrey Chen, Kristina Rafidi, Zheng Feng, Jeffrey Nickel, Jon Engebretsen, Jill Hallin, Alessandra Blasina, Eric Zhang, Leslie Nguyen, etc.

Mol Cancer Ther. 2011 Nov;10(11):2189-99.

PMID: 21750219

1

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced With Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

Amanda Herzog, Yansong Bian, Robert Vander Broek, Bradford Hall, Jamie Coupar, Hui Cheng, Anastasia L Sowers, John D Cook, James B Mitchell, Zhong Chen, Ashok B Kulkarni, Carter Van Waes

Clin Cancer Res. 2013 Jul 15;19(14):3808-19.

PMID: 23640975

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