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PF-05105679

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For Research Use Only | Not For Clinical Use
CATAP1398583317
CAS1398583-31-7
Molecular Weight428.45
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

A Cross-Species Translational Pharmacokinetic-Pharmacodynamic Evaluation of Core Body Temperature Reduction by the TRPM8 Blocker PF-05105679

James R Gosset, Kevin Beaumont, Tomomi Matsuura, Wendy Winchester, Neil Attkins, Sophie Glatt, Ian Lightbown, Kristina Ulrich, Sonia Roberts, Jolie Harris, Emir Mesic, Tamara van Steeg, Diana Hijdra, Piet H van der Graaf

Eur J Pharm Sci. 2017 Nov 15;109S:S161-S167.

PMID: 28603038

1

Discovery of a Selective TRPM8 Antagonist With Clinical Efficacy in Cold-Related Pain

Mark D Andrews, Kerry Af Forselles, Kevin Beaumont, Sébastien R G Galan, Paul A Glossop, Mathilde Grenie, Alan Jessiman, Amy S Kenyon, Graham Lunn, Graham Maw, Robert M Owen, David C Pryde, Dannielle Roberts, etc.

ACS Med Chem Lett. 2015 Jan 30;6(4):419-24.

PMID: 25893043

1

Inhibition of TRPM8 Channels Reduces Pain in the Cold Pressor Test in Humans

Wendy J Winchester, Katrina Gore, Sophie Glatt, Wendy Petit, Jennifer C Gardiner, Kelly Conlon, Michael Postlethwaite, Pierre-Philippe Saintot, Sonia Roberts, James R Gosset, Tomomi Matsuura, Mark D Andrews, etc.

J Pharmacol Exp Ther. 2014 Nov;351(2):259-69.

PMID: 25125580

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