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PF-05180999

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For Research Use Only | Not For Clinical Use
CATAP1394033545
CAS1394033-54-5
Molecular Weight414.39
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Effect of Phosphodiesterase (1B, 2A, 9A and 10A) Inhibitors on Central Nervous System Cyclic Nucleotide Levels in Rats and Mice

Jie Chen, Douglas Zook, Lindsay Crickard, Ali Tabatabaei

Neurochem Int. 2019 Oct;129:104471.

PMID: 31121256

1

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Christopher J Helal, Eric Arnold, Tracey Boyden, Cheng Chang, Thomas A Chappie, Ethan Fisher, Mihaly Hajos, John F Harms, William E Hoffman, John M Humphrey, Jayvardhan Pandit, Zhijun Kang, Robin J Kleiman, etc.

J Med Chem. 2018 Feb 8;61(3):1001-1018.

PMID: 29293004

1

Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme

Laigao Chen, Nabeel Nabulsi, Mika Naganawa, Kenneth Zasadny, Marc B Skaddan, Lei Zhang, Soheila Najafzadeh, Shu-Fei Lin, Christopher J Helal, Tracey L Boyden, Cheng Chang, Jim Ropchan, Richard E Carson, etc.

J Nucl Med. 2016 Sep;57(9):1448-53.

PMID: 27199356

1

Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat

Guibao Gu, Trevor Scott, Yingzhuo Yan, Noelle Warren, Adia Zhang, Ali Tabatabaei, Hao Xu, Kathleen Aertgeerts, Laurent Gomez, Andrew Morse, Yu-Wen Li, J Guy Breitenbucher, Eben Massari, Jeffrey Vivian, etc.

J Pharmacol Exp Ther. 2019 Sep;370(3):399-407.

PMID: 31253692

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